Pharmacology and Toxicology Department Highlights: April 2021

(April 1, 2021)

Publications

Predicting Drug Interactions with Human Equilibrative Nucleoside Transporters 1 and 2 Using Functional Knockout Cell Lines and Bayesian Modeling. Molecular Pharmacology. Vol. 99, Issue 2, 1 Feb 2021.

Design and Comprehensive Characterization of Tetramethylpyrazine (TMP) for Targeted Lung Delivery as Inhalation Aerosols in Pulmonary Hypertension (PH): In Vitro Human Lung Cell Culture and In Vivo EfficacyAntioxidants: Special Theme Issue: Antioxidants and Lung Diseases (2021) 10 (3) 427.

Advanced therapeutic inhalation aerosols of a Nrf2 activator and RhoA/Rho kinase (ROCK) inhibitor for targeted pulmonary drug delivery in pulmonary hypertension: design, characterization, aerosolization, in vitro 2D/3D human lung cell cultures, and in vivo efficacyTherapeutic Advances in Respiratory Disease (2021) 15:1-25. PMID: 33719747

Boceprevir, calpain inhibitors II and XII, and GC-376 have broad-spectrum antiviral activity against coronaviruesbioRxiv. (2020) Nov 1. PMID: 33140049

The in vitro antiviral activity of lactoferrin against common human coronaviruses and SARS-CoV-2 is mediated by targeting the heparan sulfate co-receptorEmerging Microbes & Infections (2021), 10(1)

Dipyridamole, chloroquine, montelukast sodium, candesartan, oxytetracycline, and atazanavir are not SARS-CoV-2 main protease inhibitorsPNAS (2021) February 23 118 (8) e2024420118

Deuterium Oxide (D 2 O) Induces Early Stress Response Gene Expression and Impairs Growth and Metastasis of Experimental Malignant MelanomaCancers (2021) Feb 3; 13(4):605

FAM129B‐dependent activation of NRF2 promotes an invasive phenotype in BRAF mutant melanoma cellsMolecular Carcinogenesis (2021) Mar 8. PMID: 33684228


Presentations

Discover Pharmacy BSPS Virtual Open House

Heidi Mansour, PhD, RPh

Jun Wang, PhD

  • Drug discovery and pharmacology of antivirals targeting influenza virus, enterovirus D68, and SARS-CoV-2. Feb 4th, 2021 - Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy at the Purdue University
  • SARS-CoV-2 antiviral drug discovery targeting the main protease and papain-like protease. Feb 27, 2021 - Chinese-American Bio/Pharmaceutical Society Webinar: COVID-19 small molecule drug discovery
  • SARS-CoV-2 antiviral drug discovery targeting the main protease and papain-like protease. Feb 27, 2021 - 18th Hellenic Symposium on Medicinal Chemistry (Greece)
  • SARS-CoV-2 antiviral drug discovery targeting the main protease and papain-like protease. Feb 24, 2021 - 6th Annual ABRC-Flinn Research Conference