James Galligan, PhD

Assistant Professor, Pharmacology and Toxicology

James Galligan, PhD, assistant professor, Department of Pharmacology and Toxicology—studies the link between cellular metabolism, environmental genetics and disease etiology. Keenly interested in post-translational modifications, his research focuses on reactive metabolites deleterious cell health. Current work centers on histone modifications derived from cell metabolism in diabetes and cancer.

Recipient of several Society for Free Radical Biology and Medicine Young Investigator Awards, he’s also received the Harold C. Hein Award for Outstanding Performance in Graduate Studies and Research and Norman Weiner Graduate Student Award for Research Excellence. His numerous journal articles and presentations focus on histones, oxidative stress and cell metabolism.

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Education & Post Graduate Training: 

Postdoc, Biochemistry, Vanderbilt University (Tennessee), 2016
PhD, Pharmacology, University of Colorado, 2012
BS, Physiology, Michigan State University, 2006

Areas of Research: 

Cellular metabolism
Epigentics
Enzymatic Regulation
Liver Disease
Metabolites
Post-translational modifications
Histones
Mass Spectrometry
Proteomics
Hyperglycemia

Select Publications

2018

Galligan, J. J., J. A. Wepy, M. D. Streeter, P. J. Kingsley, M. M. Mitchener, O. R. Wauchope, W. N. Beavers, K. L. Rose, T. Wang, D. A. Spiegel, et al., "Methylglyoxal-derived posttranslational arginine modifications are abundant histone marks.", Proc Natl Acad Sci U S A, vol. 115, issue 37, pp. 9228-9233, 2018 Sep 11. PMID: 30150385

2017

Galligan, J. J., P. J. Kingsley, O. R. Wauchope, M. M. Mitchener, J. M. Camarillo, J. A. Wepy, P. S. Harris, K. S. Fritz, and L. J. Marnett, "Quantitative Analysis and Discovery of Lysine and Arginine Modifications.", Anal Chem, vol. 89, issue 2, pp. 1299-1306, 2017 Jan 17. PMCID: PMC5309163  PMID: 27982582
Beavers, W. N., K. L. Rose, J. J. Galligan, M. M. Mitchener, C. A. Rouzer, K. A. Tallman, C. R. Lamberson, X. Wang, S. Hill, P. T. Ivanova, et al., "Protein Modification by Endogenously Generated Lipid Electrophiles: Mitochondria as the Source and Target.", ACS Chem Biol, vol. 12, issue 8, pp. 2062-2069, 2017 08 18. PMID: 28613820
Galligan, J. J., and L. J. Marnett, "Histone Adduction and Its Functional Impact on Epigenetics.", Chem Res Toxicol, vol. 30, issue 1, pp. 376-387, 2017 01 17. PMCID: PMC5257195  PMID: 27930886

2014

Galligan, J. J., K. L. Rose, W. N. Beavers, S. Hill, K. A. Tallman, W. P. Tansey, and L. J. Marnett, "Stable histone adduction by 4-oxo-2-nonenal: a potential link between oxidative stress and epigenetics.", J Am Chem Soc, vol. 136, issue 34, pp. 11864-6, 2014 Aug 27. PMCID: PMC4151707  PMID: 25099620

2012

Galligan, J. J., R. L. Smathers, K. S. Fritz, L. E. Epperson, L. E. Hunter, and D. R. Petersen, "Protein carbonylation in a murine model for early alcoholic liver disease.", Chem Res Toxicol, vol. 25, issue 5, pp. 1012-21, 2012 May 21. PMCID: PMC3423195  PMID: 22502949