James Galligan, PhD

Assistant Professor, Pharmacology and Toxicology

James Galligan, PhD, assistant professor, Department of Pharmacology and Toxicology—studies the link between cellular metabolism, environmental genetics and disease etiology. Keenly interested in post-translational modifications, his research focuses on reactive metabolites deleterious cell health. Current work centers on histone modifications derived from cell metabolism in diabetes and cancer.

Recipient of several Society for Free Radical Biology and Medicine Young Investigator Awards, he’s also received the Harold C. Hein Award for Outstanding Performance in Graduate Studies and Research and Norman Weiner Graduate Student Award for Research Excellence. His numerous journal articles and presentations focus on histones, oxidative stress and cell metabolism.

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Education & Post Graduate Training: 

Postdoc, Biochemistry, Vanderbilt University (Tennessee), 2016
PhD, Pharmacology, University of Colorado, 2012
BS, Physiology, Michigan State University, 2006

Areas of Research: 

Cellular metabolism
Epigentics
Enzymatic Regulation
Liver Disease
Metabolites
Post-translational modifications
Histones
Mass Spectrometry
Proteomics
Hyperglycemia

Select Publications

2020

Maksimovic I, Zheng Q, Trujillo MN, Galligan JJ, David Y. "An Azidoribose Probe to Track Ketoamine Adducts in Histone Ribose Glycation." J. Am. Chem. Soc.. 2020. PMID: 32390412

2019

Gaffney DO, Jennings EQ, Anderson CC, et al. "Non-enzymatic Lysine Lactoylation of Glycolytic Enzymes." Cell Chem Biol. 2019;27(2):206-213.e6. PMID: 31767537

2018

Galligan JJ, Wepy JA, Streeter MD, et al. "Methylglyoxal-derived posttranslational arginine modifications are abundant histone marks." Proc. Natl. Acad. Sci. U.S.A.. 2018;115(37):9228-9233. PMID: 30150385

2017

Galligan JJ, Kingsley PJ, Wauchope OR, et al. "Quantitative Analysis and Discovery of Lysine and Arginine Modifications." Anal. Chem.. 2017;89(2):1299-1306. PMCID: PMC5309163  PMID: 27982582
Beavers WN, Rose KL, Galligan JJ, et al. "Protein Modification by Endogenously Generated Lipid Electrophiles: Mitochondria as the Source and Target." ACS Chem. Biol.. 2017;12(8):2062-2069. PMID: 28613820
Galligan JJ, Marnett LJ. "Histone Adduction and Its Functional Impact on Epigenetics." Chem. Res. Toxicol.. 2017;30(1):376-387. PMCID: PMC5257195  PMID: 27930886

2014

Galligan JJ, Rose KL, Beavers WN, et al. "Stable histone adduction by 4-oxo-2-nonenal: a potential link between oxidative stress and epigenetics." J. Am. Chem. Soc.. 2014;136(34):11864-6. PMCID: PMC4151707  PMID: 25099620

2012

Galligan JJ, Smathers RL, Fritz KS, Epperson LE, Hunter LE, Petersen DR. "Protein carbonylation in a murine model for early alcoholic liver disease." Chem. Res. Toxicol.. 2012;25(5):1012-21. PMCID: PMC3423195  PMID: 22502949