James Galligan, PhD

Assistant Professor, Pharmacology and Toxicology

James Galligan, PhD, assistant professor, Department of Pharmacology and Toxicology—studies the link between cellular metabolism, environmental genetics and disease etiology. Keenly interested in post-translational modifications, his research focuses on reactive metabolites deleterious cell health. Current work centers on histone modifications derived from cell metabolism in diabetes and cancer.

Recipient of several Society for Free Radical Biology and Medicine Young Investigator Awards, he’s also received the Harold C. Hein Award for Outstanding Performance in Graduate Studies and Research and Norman Weiner Graduate Student Award for Research Excellence. His numerous journal articles and presentations focus on histones, oxidative stress and cell metabolism.

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Education & Post Graduate Training: 

Postdoc, Biochemistry, Vanderbilt University (Tennessee), 2016
PhD, Pharmacology, University of Colorado, 2012
BS, Physiology, Michigan State University, 2006

Areas of Research: 

Cellular metabolism
Enzymatic Regulation
Liver Disease
Post-translational modifications
Mass Spectrometry

Select Publications


Jennings EQ, Ray JD, Zerio CJ, et al. "Sirtuin 2 Regulates Protein LactoylLys Modifications." Chembiochem. 2021;22(12):2102-2106. PMCID: PMC8205944  PMID: 33725370


Maksimovic I, Zheng Q, Trujillo MN, Galligan JJ, David Y. "An Azidoribose Probe to Track Ketoamine Adducts in Histone Ribose Glycation." J. Am. Chem. Soc.. 2020. PMID: 32390412


Gaffney DO, Jennings EQ, Anderson CC, et al. "Non-enzymatic Lysine Lactoylation of Glycolytic Enzymes." Cell Chem Biol. 2019;27(2):206-213.e6. PMID: 31767537


Galligan JJ, Wepy JA, Streeter MD, et al. "Methylglyoxal-derived posttranslational arginine modifications are abundant histone marks." Proc. Natl. Acad. Sci. U.S.A.. 2018;115(37):9228-9233. PMID: 30150385


Galligan JJ, Kingsley PJ, Wauchope OR, et al. "Quantitative Analysis and Discovery of Lysine and Arginine Modifications." Anal. Chem.. 2017;89(2):1299-1306. PMCID: PMC5309163  PMID: 27982582