Heidi Mansour, PhD, RPh

Associate Professor with Tenure, Pharmaceutical Sciences
Associate Professor, College of Medicine
Associate Member, UA NCI Comprehensive Cancer Center
Affiliate Faculty Member, UA Institute of the Environment
Associate Professor, UA BIO5 Research Institute
Track Director, Pharmaceutics and Pharmacokinetics

Dr. Mansour is an associate professor of tenure. She teaches in the PharmD program and in the Pharmaceutics and Pharmacokinetics track of the graduate program. 

Research in the Mansour lab focuses on the fundamental and applied aspects of surface and interfacial chemistry, nanotechnology, and particle engineering technologies in the design and optimization of advanced drug delivery systems. Multifunctional polymeric phospholipid (lipopolymeric) self-assemblies are optimized for targeted drug delivery, nanomedicine, and multifunctional microparticles and nanoparticles in the solid-state as dry powder inhalation aerosols in the targeted treatment and prevention of several pulmonary diseases. These microparticulate/nanoparticulate dry powders, which are targeted directly to the lung as dry powder inhalers, are biocompatible, biodegradable, mucopenetrating, and provide sustained drug release.

We utilize various types of inhaler devices for both in vitro and in vivo rodent animal models. A systematic Quality-by-Design (QbD) approach in the solid-state is used and includes comprehensive physicochemical characterization, design of experiments (DOEs), performance modeling, and prediction. Pulmonary diseases with unmet medical needs that we investigate in vitro and in vivo include lung transplantation, lung cancer, infectious diseases, lung inflammatory fibrotic diseases, and autoimmune diseases. Our research program includes translational medicine, as exemplified by several successful collaborations with physician-scientists.

 

Education: 

Postdoctorate, University of North Carolina-Chapel Hill, 2006 - 2008
Postdoctorate, University of Wisconsin-Madison School of Pharmacy, 2004
PhD, Pharmaceutical Sciences (Pharmaceutics & Drug Delivery), University of Wisconsin-Madison, 2003
PhD, University of Wisconsin-Madison Department of Chemistry, 12/1999
BS, Pharmacy, University of Wisconsin-Madison, 1996

 

Select Publications

2016

Hayes, D., D. Tumin, C. J. Daniels, K. S. McCoy, H. M. Mansour, J. D. Tobias, and S. E. Kirkby, "Pulmonary Artery Pressure and Benefit of Lung Transplantation in Adult Cystic Fibrosis Patients.", Ann Thorac Surg, vol. 101, issue 3, pp. 1104-9, 2016 Mar.
Hayes, D., S. M. Black, J. D. Tobias, B. T. Kopp, S. E. Kirkby, H. M. Mansour, and B. A. Whitson, "Influence of human leukocyte antigen mismatching on bronchiolitis obliterans syndrome in lung transplantation.", J Heart Lung Transplant, vol. 35, issue 2, pp. 186-94, 2016 Feb.
Muralidharan, P., D. Hayes, S. M. Black, and H. M. Mansour, "Microparticulate/Nanoparticulate Powders of a Novel Nrf2 Activator and an Aerosol Performance Enhancer for Pulmonary Delivery Targeting the Lung Nrf2/Keap-1 Pathway.", Mol Syst Des Eng, vol. 1, issue 1, pp. 48-65, 2016. PMCID: PMC5072457  PMID: 27774309
Meenach, S. A., A. N. Tsoras, R. C. McGarry, H. M. Mansour, Z. J Hilt, and K. W. Anderson, "Development of three-dimensional lung multicellular spheroids in air- and liquid-interface culture for the evaluation of anticancer therapeutics.", Int J Oncol, vol. 48, issue 4, pp. 1701-9, 2016 Apr. PMCID: PMC4777598  PMID: 26846376
de la Vega, M. Rojo, M. Dodson, C. Gross, H. Mansour, C. R Lantz, E. Chapman, T. Wang, S. M. Black, J. G. N. Garcia, and D. D. Zhang, "Role of Nrf2 and Autophagy in Acute Lung Injury.", Curr Pharmacol Rep, vol. 2, issue 2, pp. 91-101, 2016 04. PMCID: PMC4905711  PMID: 27313980
Hayes, D., D. Tumin, A. R. Yates, H. M. Mansour, K. K. Nicol, J. D. Tobias, and A. F. Palmer, "Transfusion with packed red blood cells while awaiting lung transplantation is associated with reduced survival after lung transplantation.", Clin Transplant, vol. 30, issue 12, pp. 1545-1551, 2016 Dec.
Hayes, D., P. I. McConnell, A. R. Yates, J. D. Tobias, M. Galantowicz, H. M. Mansour, and D. Tumin, "Induction immunosuppression for combined heart-lung transplantation.", Clin Transplant, vol. 30, issue 10, pp. 1332-1339, 2016 Oct.
Hayes, D., B. T. Kopp, S. E. Kirkby, S. D. Reynolds, H. M. Mansour, J. D. Tobias, and D. Tumin, "Impact of Donor Arterial Partial Pressure of Oxygen on Outcomes After Lung Transplantation in Adult Cystic Fibrosis Recipients.", Lung, vol. 194, issue 4, pp. 547-53, 2016 Aug.
Hayes, D., B. R. Younger, H. M. Mansour, and H. Strawbridge, "Precordial Catch Syndrome in Elite Swimmers With Asthma.", Pediatr Emerg Care, vol. 32, issue 2, pp. 104-6, 2016 Feb.
Acosta, M. F., P. Muralidharan, S. A. Meenach, D. Hayes, S. M-Black, and H. M. Mansour, "In Vitro Pulmonary Cell Culture in Pharmaceutical Inhalation Aerosol Delivery: 2-D, 3-D, and In Situ Bioimpactor Models.", Curr Pharm Des, vol. 22, issue 17, pp. 2522-31, 2016.