Eli Chapman, PhD

Associate Professor, Pharmacology and Toxicology

The Chapman lab is a chemical biology lab. They are primarily focused on finding synthetic small molecules or natural probes and leads through targeted approaches, on understanding the mechanisms and modes of action of these molecules, and on improving the molecules through medicinal chemistry. We use contemporary molecular biology and protein biochemistry procedures to produce the desired target proteins and then develop assays amenable to moderate to high throughput screening. Through development, we use cellular amenable to understand the modes of action, biophysics to understand the mechanisms of action, structural biology to guide molecular improvements, and synthetic chemistry to optimize hit compounds. We often simultaneously probe families of enzymes in a parallel fashion in an effort to pre-program specificity, mitigating downstream off-target liabilities and aiding development. Currently, we have several programs in the lab including antibiotics targeting bacterial HSP60 (GroEL); anti-cancer targeting specific HSP70s, elF4A, and NRF2; and anti-type 2 diabetes targeting PTP1B. 

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Education & Post Graduate Training: 

BS, Chemistry, University of California at Berkeley, 1996
MA, Chemistry, Columbia University (New York), 1998
PhD, Chemistry, Scripps Research Institute (California), 2003

Select Publications

2017

Tillotson J, Kedzior M, Guimarães L, et al. "ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A." Bioorg. Med. Chem. Lett.. 2017;27(17):4082-4085. PMCID: PMC5593424  PMID: 28757063
Tillotson J, Zerio CJ, Harder B, et al. "Arsenic Compromises Both p97 and Proteasome Functions." Chem. Res. Toxicol.. 2017;30(7):1508-1514. PMCID: PMC5687067  PMID: 28636814
Tao S, Liu P, Luo G, et al. "p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex." Mol. Cell. Biol.. 2017;37(8). PMCID: PMC5376629  PMID: 28115426
Ambrose AJ, Santos EA, Jimenez PC, et al. "Ritterostatin GN 1N , a Cephalostatin-Ritterazine Bis-steroidal Pyrazine Hybrid, Selectively Targets GRP78." Chembiochem. 2017;18(6):506-510. PMCID: PMC5562448  PMID: 28074539

2016

Tillotson J, Bashyal BP, Kang MJ, et al. "Selective inhibition of p97 by chlorinated analogues of dehydrocurvularin." Org. Biomol. Chem.. 2016;14(25):5918-21. PMCID: PMC5466822  PMID: 27223265