Asymmetric α-benzoyloxylation of β-ketocarbonyls by a chiral primary amine catalyst.

Reference

Wang, L., Xu, Y.- ming, Zhang, D., & Luo, G. (2015). Asymmetric α-benzoyloxylation of β-ketocarbonyls by a chiral primary amine catalyst. 17(3). https://doi.org/10.1021/ol503592n

Abstract

The direct asymmetric α-benzoyloxylation of β-ketocarbonyls catalyzed by a chiral primary amine is described herein. This protocol demonstrates excellent enantioselectivity for a broad range of substrates, which allows convenient access to highly enantioenriched α-hydroxy-β-ketocarbonyls.