Pharmacology and Toxicology Department Highlights: December 2020
(December 1, 2020)
Publications
Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against M pro and cathepsin L. Sci Adv. 2020 Nov 6:eabe0751. Online ahead of print. PMID: 33158912
- Sacco, MD.
- Ma, C.
- Lagarias, P.
- Gao, A.
- Townsend, JA.
- Meng, X.
- Dube, P.
- Zhang, X.
- Hu, Y.
- Kitamura, N.
- Hurst, B.
- Tarbet, B.
- Marty, MT.
- Kolocouris, A.
- Xiang, Y.
- Chen, Y.
- Jun Wang, PHD
Ebselen, disulfiram, carmofur, PX-12, tideglusib, and shikonin are non-specific promiscuous SARS-CoV-2 main protease inhibitors. ACS Pharmacol. Transl. Sci. ASAP.
- Ma, C.
- Hu, Y.
- Townsend, J.
- Lagarias, P.
- Marty, M.
- Kolocouris, A.
- Jun Wang, PHD
Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease. Cell Res. 2020 Aug;30(8):678-692. Epub 2020 Jun 15. PMID: 32541865
- Ma, C.
- Sacco, MD.
- Hurst, B.
- Townsend, JA.
- Hu, Y.
- Szeto, T.
- Zhang, X.
- Tarbet, B.
- Marty, MT.
- Chen, Y.
- Jun Wang, PHD
Chemical Probes for Blocking of Influenza A M2 Wild-type and S31N Channel. ACS Chem. Biol. 2020 Sep 18;15(9):2331-2337. Epub 2020 Aug 27. PMID: 32786258.
- Tzitzoglaki, C.
- McGuire, K.
- Lagarias, P.
- Konstantinidi, A.
- Hoffmann, A.
- Fokina, NA.
- Ma, C.
- Papanastasiou, I.
- Schreiner, PR.
- Vázquez, S.
- Schmidtke, M.
- Jun Wang, PHD
- Busath, DD.
- Kolocouri, A.
Crosstalk Between Obstructive Sleep Apnea and Comorbid Hypertension, Remodeling, and Ischemic Stroke; Matrix Metalloproteinase-9 as a Messenger. Journal of Clinical Sleep Medicine (2020) Oct 27. PMID: 33108267
- Saif Mashaqi, MD
- Heidi Mansour, PhD, RPh
- Alameddin. H.
- DAniel Combs, MD
- Patel, S.
- Estep, L.
- Sairam Parthasarathy, MD
Advanced Spray-Dried Proliposomes of Amphotericin B as Microparticles/Nanoparticles as Dry Powder Inhalers for Targeted Pulmonary Drug Delivery. Pulmonary Pharmacology & Therapeutics (2020) Oct 31;64:101975. PMID: 33137515
- Gomez, AI.
- Acosta, M.
- Muralidharan, P.
- Jason Yuan, PhD
- Stephen Black, PhD
- Don Hayes, Jr., MD, MS, MEd
- Heidi Mansour, PhD, RPh
Design and Development of Innovative Microparticulate/Nanoparticulate Inhalable Dry Powders of a Novel Synthetic Trifluorinated Chalcone Derivative and Nrf2 Agonist. Scientific Reports (2020) 10(1):19771. PMID: 33188247
- Muralidharan, P.
- Jones, B.
- Allaway, G.
- Shyam Biswal, PhD
- Heidi Mansour, PhD, RPh
Inhalable Nanoparticles/Microparticles of an AMPK and Nrf2 Activator for Targeted Pulmonary Drug Delivery as Dry Powder Inhalers. The AAPS Journal: Special Theme Issue: Celebrating Women in the Pharmaceutical Sciences (2021) 23: Article 2.
- Acosta, M.
- Abrahamson, MD.
- David Encinas-Basurto, PhD
- Fineman, JR.
- Stephen Black, PhD
- Heidi Mansour, PhD, RPh
Advanced Nanoparticle/Microparticle Dual-Drug Combination Lactose Carrier-Free Dry Powder Inhalation Aerosols. RSC Advances (2020) 10: 41846-41856.
- Muralidharan, P.
- Mallory, EK.
- Malapit, M.
- Phan, H.
- Julie Ledford, PhD
- Don Hayes, Jr., MD, MS, MEd
- Heidi Mansour, PhD, RPh
Kudos
- Nominated as a Candidate for APhA-APRS Basic Sciences Section Chair-Elect (2022-2023) in the 2021 election (see press release)
- Elected to the editorial board of the European Journal of Pharmaceutical Sciences.