Heidi Mansour, PhD, RPh

Associate Professor with Tenure, Pharmaceutical Sciences
Associate Professor, College of Medicine
Associate Professor, Clinical Translational Sciences
Therapeutic Development Program Research Member, UA NCI Comprehensive Cancer Center
Affiliate Faculty Member, UA Institute of the Environment
Associate Professor, UA BIO5 Research Institute
Track Director, Pharmaceutics and Pharmacokinetics
Director, PharmD/PhD Dual-Degree Joint Program

Heidi Mansour, PhD, RPh, associate professor with tenure, Department of Pharmacology and Toxicology, serves as associate professor, College of Medicine, Clinical Translational Sciences and at the BIO5 Institute. Other appointments include track director, pharmaceutics and pharmacokinetics; associate member, NCI Comprehensive Cancer Center; affiliate faculty member, Institute of Environment and director, PharmD/PhD dual-degree joint program. As PI on multiple NIH, NSF, FDA, and pharmaceutical industrial grants, Dr. Mansour successfully leads multiple cutting-edge research projects. Her innovative research program has produced Assistant Professors who are employed at major research universities in the United States and in the Republic of S. Korea. In addition, her research program has produced Senior Research Scientists who are employed in major pharmaceutical companies in the United States. As Postdoc Mentor, Dr. Mansour has successfully mentored and trained over 10 Postdoctoral Research Scholars in my research program.  As Major Professor, Dr. Mansour has successfully trained and graduated 3 doctoral graduate students with PhD degrees. Her mentoring experience extends as an active faculty mentor in the ATS Assembly Mentorship Program for several mentees in the ATS Assemblies each year.

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    Dr. Heidi M. Mansour in the news:

    Education & Post Graduate Training: 

    Post-Doctoral, Molecular Pharmaceutics, University of North Carolina, 2008
    Post-Doctoral, Pharmaceutical Science, University of Wisconsin, 2004
    PhD Major, Pharmaceutics/Drug Delivery, University of Wisconsin, 2003
    PhD Minor, Advanced Physical and Interfacial Chemistry, University of Wisconsin, 1999
    BS, Pharmacy, University of Wisconsin, 1996

    Research Summary: 

    Editorial Advisory Board member of several journals, Mansour’s authored over 90 peer-reviewed journal publications, 13 book chapters, and co-edited 2 books. She serves on the drug-device discovery and development committee for the American Thoracic Society and annual faculty instructor, International Society of Aerosols in Medicine where she co-chaired the drug delivery: new devices and emerging therapies group.

    Books

    • Inhalation Aerosols: Physical and Biological Basis for Therapy. Hickey, A. J. and Mansour, H.M. (Editors), Third Edition, Lung Biology in Health and Diseases Series, Executive Editor, Dr. Claude Lenfant, CRC Press/Taylor & Francis, London, United Kingdom. (2019) 418 pages. ISBN 9781138064799
    • Nanomedicine in Drug Delivery. Kumar, A., Mansour, H.M., Friedman, A., and Blough, E. (Editors), CRC Press/Taylor & Francis, London, United Kingdom. (2013) 469 pages. ISBN: 9781466506169

    Patents/Inventions

    Areas of Research: 

    Cystic fibrosis
    Inhaled medical aerosols
    Lung transplantation
    Microparticulates/nanoparticulates
    Pulmonary hypertension
    Nanotechnology and nanomedicine
    Lung surfactant and respiratory distress syndrome
    Asthma
    Infectious diseases
    Acute lung injury
    CNS and brain neurotherapeutics
    Inhaled medical aerosols and inhaler devices
    Advanced drug delivery systems
    Drug-device combination products
    In vitro USP/FDA performance testing
    In vitro 2-D/3-D human cellular models for drug transport
    In vivo animal models for PK/PD

    Select Publications

    2021

    Alabsi W, Al-Obeidi FA, Polt R, Mansour HM. "Organic Solution Advanced Spray-Dried Microparticulate/Nanoparticulate Dry Powders of Lactomorphin for Respiratory Delivery: Physicochemical Characterization, In Vitro Aerosol Dispersion, and Cellular Studies." Pharmaceutics. 2021;13(1). PMID: 33375607

    2020

    Mitchell JP, Berlinski A, Canisius S, et al. "An Urgent Appeal to Clinical Decision-Makers and Governmental Agencies Involved with Public Health to Consider the Potential for Medication Delivery in the Context of COVID-19 Therapies Using the Inhaled Route of Administration." J Aerosol Med Pulm Drug Deliv. 2020;33(4):235-238. PMID: 32589076
    Acosta MF, Abrahamson MD, Encinas-Basurto D, Fineman JR, Black SM, Mansour HM. "Inhalable Nanoparticles/Microparticles of an AMPK and Nrf2 Activator for Targeted Pulmonary Drug Delivery as Dry Powder Inhalers." AAPS J. 2020;23(1):2. PMCID: PMC7669792  PMID: 33200330
    Mashaqi S, Mansour HM, Alameddin H, et al. "Matrix metalloproteinase-9 as a messenger in the crosstalk between obstructive sleep apnea and comorbid systemic hypertension, cardiac remodeling, and ischemic stroke: a literature review." J Clin Sleep Med. 2020. PMID: 33108267
    Gomez AI, Acosta MF, Muralidharan P, et al. "Advanced Spray Dried Proliposomes of Amphotericin B Lung Surfactant-Mimic Phospholipid Microparticles/Nanoparticles as Dry Powder Inhalers for Targeted Pulmonary Drug Delivery." Pulm Pharmacol Ther. 2020:101975. PMID: 33137515
    Muralidharan P, Jones B, Allaway G, Biswal SS, Mansour HM. "Design and development of innovative microparticulate/nanoparticulate inhalable dry powders of a novel synthetic trifluorinated chalcone derivative and Nrf2 agonist." Sci Rep. 2020;10(1):19771. PMID: 33188247
    Muralidharan P, Mallory EK, Malapit M, et al. "Advanced design and development of nanoparticle/microparticle dual-drug combination lactose carrier-free dry powder inhalation aerosols." RSC Adv. 2020;10(68):41846-41856. PMCID: PMC7689944  PMID: 33391731

    2019

    Hayes D, Nance AE, Mansour HM. "Sigh Syndrome in Pediatric Asthma." Lung. 2019;197(1). PMID: 30511251
    Muralidharan P, Hayes, Jr D., Mansour HM. "Pulmonary Fibrosis.". In: Inhalation Aerosols: Physical and Biological Basis for Therapy. Third Edition. London, UK: CRC Press/Taylor & Francis; 2019. Lung Biology in Health and Diseases Series.
    Acosta MF, Hayes, Jr D., Fineman J, Yuan JX-J, Black SM, Mansour HM. "Therapeutics in Pulmonary Hypertension.". In: Inhalation Aerosols: Physical and Biological Basis for Therapy. Third Edition. London, UK: CRC Press/Taylor & Francis; 2019. Lung Biology in Health and Diseases Series.