Heidi Mansour, PhD, RPh

Associate Professor with Tenure, Pharmaceutical Sciences
Associate Professor, College of Medicine
Associate Professor, Clinical Translational Sciences
Therapeutic Development Program Research Member, UA NCI Comprehensive Cancer Center
Affiliate Faculty Member, UA Institute of the Environment
Associate Professor, UA BIO5 Research Institute
Track Director, Pharmaceutics and Pharmacokinetics
Director, PharmD/PhD Dual-Degree Joint Program

Heidi Mansour, PhD, RPh, associate professor with tenure, Department of Pharmacology and Toxicology, serves as associate professor, College of Medicine, Clinical Translational Sciences and at the BIO5 Institute. Other appointments include track director, pharmaceutics and pharmacokinetics; associate member, NCI Comprehensive Cancer Center; affiliate faculty member, Institute of Environment and director, PharmD/PhD dual-degree joint program. As PI on multiple NIH, NSF, FDA, and pharmaceutical industrial grants, Dr. Mansour successfully leads multiple cutting-edge research projects. Her innovative research program has produced Assistant Professors who are employed at major research universities in the United States and in the Republic of S. Korea. In addition, her research program has produced Senior Research Scientists who are employed in major pharmaceutical companies in the United States. As Postdoc Mentor, Dr. Mansour has successfully mentored and trained 12 Postdoctoral Research Scholars in my research program.  As Major Professor, Dr. Mansour has successfully trained and graduated 5 doctoral graduate students with PhD degrees. Her mentoring experience extends as an active faculty mentor in the ATS Assembly Mentorship Program for several mentees in the ATS Assemblies each year. Dr. Mansour is the Vice Chair of the American Thoracic Society (ATS) Drug/Device Discovery & Development (DDDD) Committee. Dr. Mansour also serves in Faculty Governance, as elected to the Faculty Senate and to the Nominating Committee. Dr. Mansour is Chair-Elect (2022-2023) of the American Pharmacist Association (APhA) Academy of Pharmaceutical Research and Science (APRS) Basic Sciences.

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    Dr. Heidi M. Mansour in the news:

    Education & Post Graduate Training: 

    Post-Doctoral, Molecular Pharmaceutics, University of North Carolina, 2008
    Post-Doctoral, Pharmaceutical Science, University of Wisconsin, 2004
    PhD Major, Pharmaceutics/Drug Delivery, University of Wisconsin, 2003
    PhD Minor, Advanced Physical and Interfacial Chemistry, University of Wisconsin, 1999
    BS, Pharmacy, University of Wisconsin, 1996

    Research Summary: 

    Editorial Advisory Board member of several journals, Mansour’s authored over 100 peer-reviewed journal publications, 14 book chapters, and co-edited 2 books. She serves on the drug-device discovery and development committee for the American Thoracic Society and annual faculty instructor, International Society of Aerosols in Medicine where she co-chaired the drug delivery: new devices and emerging therapies group.

    Books

    • Inhalation Aerosols: Physical and Biological Basis for Therapy. Hickey, A. J. and Mansour, H.M. (Editors), Third Edition, Lung Biology in Health and Diseases Series, Executive Editor, Dr. Claude Lenfant, CRC Press/Taylor & Francis, London, United Kingdom. (2019) 418 pages. ISBN 9781138064799
    • Nanomedicine in Drug Delivery. Kumar, A., Mansour, H.M., Friedman, A., and Blough, E. (Editors), CRC Press/Taylor & Francis, London, United Kingdom. (2013) 469 pages. ISBN: 9781466506169

    Patents/Inventions

    Areas of Research: 

    Cystic fibrosis
    Inhaled medical aerosols
    Lung transplantation
    Microparticulates/nanoparticulates
    Pulmonary hypertension
    Nanotechnology and nanomedicine
    Lung surfactant and respiratory distress syndrome
    Asthma
    Infectious diseases
    Acute lung injury
    CNS and brain neurotherapeutics
    Inhaled medical aerosols and inhaler devices
    Advanced drug delivery systems
    Drug-device combination products
    In vitro USP/FDA performance testing
    In vitro 2-D/3-D human cellular models for drug transport
    In vivo animal models for PK/PD

    Select Publications

    2021

    Muralidharan P, Acosta MF, Gomez AI, et al. "Design and Comprehensive Characterization of Tetramethylpyrazine (TMP) for Targeted Lung Delivery as Inhalation Aerosols in Pulmonary Hypertension (PH): In Vitro Human Lung Cell Culture and In Vivo Efficacy." Antioxidants (Basel). 2021;10(3). PMID: 33799587
    Acosta MF, Muralidhran P, Abrahamson MD, et al. "Comparison of L-Carnitine and L-Carnitine HCL Salt for Targeted Lung Treatment of Pulmonary Hypertension (PH) as Inhalation Aerosols: Design, Comprehensive Characterization, In Vitro 2D/3D Cell Cultures, and In Vivo MCT-Rat Model of PH." Pulm Pharmacol Ther. 2021:101998. PMID: 33556627
    Alabsi W, Al-Obeidi FA, Polt R, Mansour HM. "Organic Solution Advanced Spray-Dried Microparticulate/Nanoparticulate Dry Powders of Lactomorphin for Respiratory Delivery: Physicochemical Characterization, In Vitro Aerosol Dispersion, and Cellular Studies." Pharmaceutics. 2021;13(1). PMID: 33375607
    Acosta MF, Muralidharan P, Grijalva CL, et al. "Advanced therapeutic inhalation aerosols of a Nrf2 activator and RhoA/Rho kinase (ROCK) inhibitor for targeted pulmonary drug delivery in pulmonary hypertension: design, characterization, aerosolization, 2D/3D human lung cell cultures, and efficacy." Ther Adv Respir Dis. 2021;15:1753466621998245. PMID: 33719747
    Alabsi W, Acosta MF, Al-Obeidi FA, Hay M, Polt R, Mansour HM. "Synthesis, Physicochemical Characterization, In Vitro 2D/3D Human Cell Culture, and In Vitro Aerosol Dispersion Performance of Advanced Spray Dried and Co-Spray Dried Angiotensin (1-7) Peptide and PNA5 with Trehalose as Microparticles/Nanoparticles." Pharmaceutics. 2021;13(8). PMID: 34452239
    Hayes D, Darland LK, Hjelm MA, Mansour HM, Wikenheiser-Brokamp KA. "To treat or not to treat: CFTR modulators after lung transplantation." Pediatr Transplant. 2021:e14007. PMID: 33742748
    Eedara BBabu, Alabsi W, Encinas-Basurto D, Polt R, Ledford JG, Mansour HM. "Inhalation Delivery for the Treatment and Prevention of COVID-19 Infection." Pharmaceutics. 2021;13(7). PMCID: PMC8308954  PMID: 34371768
    Eedara BBabu, Alabsi W, Encinas-Basurto D, Polt R, Mansour HM. "Spray-Dried Inhalable Powder Formulations of Therapeutic Proteins and Peptides." AAPS PharmSciTech. 2021;22(5):185. PMID: 34143327
    Hoyer-Kimura C, Konhilas JP, Mansour HM, et al. "Neurofilament light: a possible prognostic biomarker for treatment of vascular contributions to cognitive impairment and dementia." J Neuroinflammation. 2021;18(1):236. PMID: 34654436
    Vallorz EL, Blohm-Mangone K, Schnellmann RG, Mansour HM. "Formoterol PLGA-PEG Nanoparticles Induce Mitochondrial Biogenesis in Renal Proximal Tubules." AAPS J. 2021;23(4):88. PMID: 34169439