Guest Speakers - 

Meagan McManus, PhD, of the University of Arizona

Discussion - 

"Tracking the Spark: PET Imaging of Early Mitochondrial Distress in Neurodegenerative Disease"

Mitochondria are central not only to neuronal bioenergetics but also to intercellular signaling that shapes brain aging and initiates neurodegenerative cascades. Reactive oxygen species (ROS) and other mitochondrial stress signals act as early, immunogenic mediators that couple mitochondrial inefficiency to glial activation and progressive neurodegeneration. Here I will present convergent preclinical evidence supporting [18F]ROStrace PET- a novel, blood–brain-barrier–permeant, redox-sensitive tracer- as a translational tool to noninvasively detect mito-immune distress before overt pathology in models relevant to late-onset Alzheimer’s disease (AD) and Parkinson’s disease (PD).

Attendance Options - 

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