Guest Speaker - 

Nate Snyder, PhD, from Temple University

Discussion - 

Compartmentalization of Metabolism

Abstract - 

Compartmentalization is a fundamental property of metabolism within complex systems.  Metabolism is compartmentalized within living organisms, within organs, and within subcellular compartments.  In metazoans, compartmentalization of metabolism within the mitochondria and cytosol allows opposing metabolic processes to co-exist.  Increasingly, it is recognized that the nucleus also compartmentalizes certain metabolic processes.  This suggests that one mechanism of metabolic control is via sub-cellular metabolism, and that metabolites that are both critical metabolic intermediates and signaling molecules can provide dual functions via compartmentalization.  We show how this can function by linking histone acylation and the metabolism of the central metabolic intermediates and acyl-donors acyl-Coenzyme A thioesters.  Using a combination of stable isotope labeling techniques, classical biochemistry, and analytical chemistry we demonstrate the enrichment of propionyl-CoA within the eukaryotic nuclei.  We will highlight current work on understanding how this pool is generated and work on generalizing this approach to study other compartment specific phenomena with other metabolic cofactors.

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