Pharmacology and Toxicology Department Highlights: October 2022

Nov. 1, 2022

A researcher using a syringe.

Publications

A first-in-class clinical G-quadruplex-targeting drug. The bench-to-bedside translation of the fluoroquinolone QQ58 to CX-5461 (Pidnarulex)

Hong Xu
Laurence H. Hurley

Quindoline-derivatives display potent G-quadruplex-mediated antiviral activity against herpes simplex virus

Ilaria Frasson Matteo
Nadai Martina
Tassinari Matteo Scalabrin
Vijay Gokhale
Laurence H. Hurley
Sara N. Richter

Quindoline-derivatives display potent G-quadruplex-mediated antiviral activity against herpes simplex virus

Ilaria Frasson Matteo
Nadai Martina
Tassinari Matteo Scalabrin
Vijay Gokhale
Laurence H. Hurley
Sara N. Richter

The Glycolysis-derived α-Dicarbonyl Metabolite Methylglyoxal is a UVA-photosensitizer Causing the Photooxidative Elimination of HaCaT Keratinocytes with Induction of Oxidative and Proteotoxic Stress Response Gene Expression

Lohanna de Faria Lopes
Jana Jandova
Rebecca Justiniano
Jessica Pere
Maurício S Baptista
Georg T Wondrak

In vitro airway models from mice, rhesus macaques, and humans maintain species differences in xenobiotic metabolism and cellular responses to naphthalene

Jacklyn Kelty
Nataliia Kovalchuk
Eric Uwimana
Lei Yin
Xinxin Ding
Laura Van Winkle

Differential Effects of Arsenic in Drinking Water on Mouse Hepatic and Intestinal Heme Oxygenase-1 Expression

Hui Li Xiaoyu Fan
Xiangmeng Wu
Weiguo Han
Mary Kay Amistadi
Pengfei Liu
Donna Zhang
Jon Chorover
Xinxin Ding
Qing-Yu Zhang

Assessing cytochrome P450 function using genetically engineered mouse models

Sarrah L Hannon
Xinxin Ding

Physiological Characterization of the Transporter-Mediated Uptake of the Reversible Male Contraceptive H2-Gamendazole Across the Blood-Testis Barrier

Raymond K Hau
Joseph S Tash
Gunda I Georg
Stephen H Wright
Nathan J Cherrington