Pharmacy Practice & Science Department Highlights: October 2023

Publications

Jenny Bingham
Bingham J, Grabenstein J, Leal S, Axon D. Pharmacy on the Front Lines: A Century of Pandemic Response in America. J Am Pharm Assoc (2003). 2023 Sep 11:S1544-3191(23)00297-2. PMID: 37704064

Jason Karnes
Miller E, Sampson CUO, Desai AA, Karnes JH. Differential Drug Response in Pulmonary Arterial Hypertension: The Potential for Precision Medicine. Pulm Circ. 2023 [In Press]

Giles JB, Rollin J, Martinez KL, Selleng K, Thiele T, Pouplard C, Sheppard JI, Heddle NM, Phillips EJ, Roden DM, Gruel Y, Warkentin TE, Greinacher A, Karnes JH. Laboratory and Demographic Predictors of Functional Assay Positive Status in Suspected Heparin-Induced Thrombocytopenia: A Multicenter Retrospective Cohort Study. Thromb Res. 2023; 229:198-208.

Casanova NG, Chiang SM, Gonzalez-Garay ML, Batai K, Garman L, Montgomery CG,  Ellis N, Kittles R, Bime C, Hsu A, Holland S, Lussier Y, Karnes J,  Sweiss N, Maier LA, Koth L, Moller D,  Kaminski N, Garcia JGN. Novel eQTL polymorphisms contribute to an increased risk of progressive complicated sarcoidosis in European and African descent subjects. Eur J Respir Med. 2023 [In Press]

Lynn H, Sun X, Casanova N, Bime C, Reyes-Hernon V, Lanham C, Oita R, Ramos N, Sun B, Coletta D, Camp S, Karnes J, Ellis N, Garcia JGN. Linkage of NAMPT promoter variants to eNAMPT secretion, plasma eNAMPT levels and ARDS severity. Ther Adv Respir Dis. 17:17534666231181262. 2023 PMCID: PMC10363883.

Sangam S, Sun X, Schwantes-An TH, Yegambaram M, Lu Q, Zagorski J, Morrisroe SA, Shi Y, Cook T, Fisher A, Frump AL, Coleman A, Sun Y, Liang S, Crawford H, Lutz KA, Maun AD, Pauciulo MW, Karnes JH, Chaudhary KR, Stewart DJ, Langlais PR, Jain M, Alotaibi M, Lahm T, Jin Y, Gu H, Tang H, Nichols WC, Black SM, Desai AA. SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads of Sex, Metabolism, and Genetics. Am J Respir Crit Care Med. 2023; 207(8):1055-1069. PMCID: PMC10112457

Travis Wheeler
Nord AJ, Wheeler TJ (2023) Mirage2’s high-quality spliced protein-to-genome mappings produce accurate multiple-sequence alignments of isoforms. PLOS ONE 18(5): e0285225. https://doi.org/10.1371/journal.pone.0285225 

Schimunek, J., Seidl, P., Elez, K., Hempel, T., Le, T., Noé, F., Olsson, S., Raich, L., Winter, R., Gokcan, H., Gusev, F., Gutkin, E.M., Isayev, O., Kurnikova, M.G., Narangoda, C.H., Zubatyuk, R., Bosko, I.P., Furs, K.V., Karpenko, A.D., Kornoushenko, Y.V., Shuldau, M., Yushkevich, A., Benabderrahmane, M., Bousquet-Melou, P., Bureau, R., Charton, B., Cirou, B., Gil, G., Allen, W.J., Sirimulla, S., Watowich, S., Antonopoulos, N., Epitropakis, N., Krasoulis, A., Pitsikalis, V., Theodorakis, S., Kozlovskii, I., Maliutin, A., Medvedev, A., Popov, P., Zaretckii, M., Eghbal-zadeh, H., Halmich, C., Hochreiter, S., Mayr, A., Ruch, P., Widrich, M., Berenger, F., Kumar, A., Yamanishi, Y., Zhang, K., Bengio, E., Bengio, Y., Jain, M., Korablyov, M., Liu, C., Gilles, M., Glaab, E., Barnsley, K., Iyengar, S.M., Ondrechen, M.J., Haupt, V.J., Kaiser, F., Schroeder, M., Pugliese, L., Albani, S., Athanasiou, C., Beccari, A., Carloni, P., D'Arrigo, G., Gianquinto, E., Goßen, J., Hanke, A., Joseph, B.P., Kokh, D.B., Kovachka, S., Manelfi, C., Mukherjee, G., Muñiz-Chicharro, A., Musiani, F., Nunes-Alves, A., Paiardi, G., Rossetti, G., Sadiq, S.K., Spyrakis, F., Talarico, C., Tsengenes, A., Wade, R., Copeland, C., Gaiser, J., Olson, D.R., Roy, A., Venkatraman, V., Wheeler, T.J., Arthanari, H., Blaschitz, K., Cespugli, M., Durmaz, V., Fackeldey, K., Fischer, P.D., Gorgulla, C., Gruber, C., Gruber, K., Hetmann, M., Kinney, J.E., Das, K.M.P., Pandita, S., Singh, A., Steinkellner, G., Tesseyre, G., Wagner, G., Wang, Z., Yust, R.J., Druzhilovskiy, D.S., Filimonov, D., Pogodin, P.V., Poroikov, V., Rudik, A.V., Stolbov, L.A., Veselovsky, A.V., De Rosa, M., Simone, G.D., Gulotta, M.R., Lombino, J., Mekni, N., Perricone, U., Casini, A., Embree, A., Gordon, D.B., Lei, D., Pratt, K., Voigt, C.A., Chen, K., Jacob, Y., Krischuns, T., Lafaye, P., Zettor, A., Rodríguez, M.L., White, K.M., Fearon, D., von Delft, F., Walsh, M.A., Horvath, D., Brooks, C.L., Falsafi, B., Ford, B., García-Sastre, A., Lee, S.Y., Naffakh, N., Varnek, A., Klambauer, G. and Hermans, T.M. (2023), A community effort in SARS-CoV-2 drug discovery. Mol. Inf.. Accepted Author Manuscript. https://doi.org/10.1002/minf.202300262

Presentations

Travis Wheeler
Invited talk: Agency for Science, Technology and Research (A*STAR) in Singapore. Aug 14. "Virtual Drug Screening
Invited talk: AQuI Student Seminar Series (S3) Workshop on Quantum and Biology - August 10. "The wild west of protein design and virtual drug discovery"
PharmTalk Community Lecture Series. Oct 10. "Accelerating Drug Discovery with Artificial Intelligence"

Campbell AM, Antwi PB, Davis L, Warholak T. Fixed versus random team assignments and student outcomes in a therapeutics course. Presented at the American Association of Colleges of Pharmacy Annual Meeting; Aurora, CO; July 2023.

Presented at the Falls Prevention Fair: Medications and Fall Risk. University of Arizona Health Sciences & Banner – University Medical Center Tucson; September 25, 2023

Grants

Travis Wheeler
Was awarded a subaward on a Department of Energy grant housed at Pacific Northwest National Laboratory (PI Robert Egbert). ~$300k direct over three years. 
Title: SFA-Secure Biosystems Design: Persistence Control of Engineered Functions in Complex Soil Microbiomes

Was awarded an NIH R21 award (PI Jason Karnes, Co-PI= Travis Wheeler). Two years, $275k total direct. 
Title: Discovery of Immunogenomic Associations with Disease and Differential Risk Across Diverse Populations

Jason Karnes
OT2OD036485 (PIs: Karnes [Contact], Moreno, Solomon, Subbian)        09/15/2023-08/31/2024
NIH/Office of the Director
Precision Medicine for All of Us Researchers Collective (Medicina de Precision: Colectivo de Investigadores Salud para Todos)

R21HL172036 (PIs: Karnes [Contact] and Wheeler)                09/10/2023-07/31/2025
NIH/National Heart, Lung, and Blood Institute
Discovery of Immunogenomic Associations with Disease and Differential Risk Across Diverse Populations
In this project, we perform systematic investigation of the association of human leukocyte antigen (HLA) alleles with disease, using a two-pronged approach based on the phenome-wide association study (PheWAS) in the All of Us Research Program, a large, diverse DNA biobank coupled to electronic health records.

In the News

Brian Erstad
Management of critically ill patients receiving medications for opioid use disorder
10/30/2023 | Physician's Weekly
A review study by Brian L. Erstad, PharmD, MCCM, FCCP, FASHP, BCPS, professor and head of the Department of Pharmacy Practice and Science in the R. Ken Coit College of Pharmacy, and Melody J. Glenn, MD, professor in the Department of Emergency Medicine in the College of Medicine – Tucson, found that there are no published clinical practice guidelines or consensus statements to guide decision making in patients admitted to the ICU who were receiving medications for opioid use disorder prior to admission.