Pharmacology and Toxicology Department Highlights: October 2022

Publications

A first-in-class clinical G-quadruplex-targeting drug. The bench-to-bedside translation of the fluoroquinolone QQ58 to CX-5461 (Pidnarulex)

Quindoline-derivatives display potent G-quadruplex-mediated antiviral activity against herpes simplex virus

  • Ilaria Frasson Matteo
  • Nadai Martina
  • Tassinari Matteo Scalabrin
  • Vijay Gokhale 
  • Laurence H. Hurley
  • Sara N. Richter

Quindoline-derivatives display potent G-quadruplex-mediated antiviral activity against herpes simplex virus

  • Ilaria Frasson Matteo
  • Nadai Martina
  • Tassinari Matteo Scalabrin
  • Vijay Gokhale 
  • Laurence H. Hurley
  • Sara N. Richter

The Glycolysis-derived α-Dicarbonyl Metabolite Methylglyoxal is a UVA-photosensitizer Causing the Photooxidative Elimination of HaCaT Keratinocytes with Induction of Oxidative and Proteotoxic Stress Response Gene Expression

  • Lohanna de Faria Lopes
  • Jana Jandova
  • Rebecca Justiniano
  • Jessica Pere 
  • Maurício S Baptista
  • Georg T Wondrak

In vitro airway models from mice, rhesus macaques, and humans maintain species differences in xenobiotic metabolism and cellular responses to naphthalene

  • Jacklyn Kelty 
  • Nataliia Kovalchuk 
  • Eric Uwimana 
  • Lei Yin
  • Xinxin Ding
  • Laura Van Winkle

Differential Effects of Arsenic in Drinking Water on Mouse Hepatic and Intestinal Heme Oxygenase-1 Expression

  • Hui Li Xiaoyu Fan
  • Xiangmeng Wu
  • Weiguo Han
  • Mary Kay Amistadi
  • Pengfei Liu
  • Donna Zhang
  • Jon Chorover
  • Xinxin Ding
  • Qing-Yu Zhang

Assessing cytochrome P450 function using genetically engineered mouse models

Physiological Characterization of the Transporter-Mediated Uptake of the Reversible Male Contraceptive H2-Gamendazole Across the Blood-Testis Barrier