Zheng Sun, PhD

I am currently a postdoctoral researcher doing studies on the biology of histone deacetylases (HDACs) in the context of energy metabolism and circadian rhythm. Transcriptional control mediated by nuclear hormone receptors and their co-activators/corepressors has been the main focus of studies in the field of metabolic diseases including diabetes and obesity. HDACs are one of the key components in the regulation network. Better understanding of their functions and underlying mechanism is required for future drug discovery and targeted therapy.
Pharmacology and Toxicology
Pharmacology and Toxicology
Postdoctoral Researcher, University of Pennsylvania, Philadelphia, PA
Dissertation Title: 
“Mechanistic Study of Nucleocytoplasmic Trafficking and Reversible Acetylation in Modulating the NRF2-Dependent Antioxidant Response”
1. Sun, Z., Huang, Z. and Zhang, D.D. Direct phosphorylation of Nrf2 by MAPKs has a limited contribution in modulating Nrf2-dependent antioxidant response. (2009) PLoS ONE, 4 (8): e6588.
2. Chen, W., Sun, Z., Wang, X.J., Jiang, T., Huang, Z., Fang, D. and Zhang, D.D. (2009) Direct interaction between Nrf2 and p21Cip1/WAF1 upregulates the Nrf2-mediated antioxidant response. Mol Cell, 34 (6): 663-73.
3. Sun, Z., Chin, Y.E. and Zhang, D.D. (2009) Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during antioxidant response. Mol Cell Biol, 29, 2658-2672.
4. Sun, Z., Zhang, S., Chan, J.Y. and Zhang, D.D. (2007) Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2. Mol Cell Biol, 27, 6334-6349.
5. Wang, X.J.*, Sun, Z.*, Villeneuve, N.F., Zhang, S., Zhao, F., Li, Y., Chen, W., Yi, X., Zheng, W., Wondrak, G.T., Wong, P.K. and Zhang, D.D. (2008) Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2. Carcinogenesis, 29, 1235-1243.
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