Sarah Lamore, PhD

Pharmacology and Toxicology
Pharmacology and Toxicology
Senior Scientist, AstraZeneca Boston, MA
Dissertation Title: 
“Identification of Cathepsin B and L as Novel UVA Targets Upstream of Cutaneous Lysosomal-Autophagic Dysregulation”
Honors and Achievements: 
1. Arizona Science Foundation Graduate Research Fellowship, 2007-08.
2. Mountain West Regional Chapter Predoctoral Student Platform Presentation Award, 2nd Place, 2010.
3. NIEHS Training Grant - Environmental Toxicology of Human Diseases, 2010 (30).
4. Graduate Track Awards: Academic Excellence, 2011-12.
1. UVA causes dual inactivation of cathepsin B and L underlying lysosomal dysfunction in human dermal fibroblasts. Lamore SD, Wondrak GT. J Photochem Photobiol B. 2013 Jun 5;123:1-12. Epub 2013 Mar 28.
2. D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Qiao S, Cabello CM, Lamore SD, Lesson JL, Wondrak GT.Apoptosis. 2012 Oct;17(10):1079-94. doi: 10.1007/s10495-012-0746-x.
3. Thiostrepton is an inducer of oxidative and proteotoxic stress that impairs viability of human melanoma cells but not primary melanocytes. Qiao S, Lamore SD, Cabello CM, Lesson JL, Muñoz-Rodriguez JL, Wondrak GT.Biochem Pharmacol. 2012 May 1;83(9):1229-40. doi: 10.1016/j.bcp.2012.01.027. Epub 2012 Feb 1.
4. Autophagic-lysosomal dysregulation downstream of cathepsin B inactivation in human skin fibroblasts exposed to UVA. Lamore SD, Wondrak GT.Photochem Photobiol Sci. 2012 Jan;11(1):163-72. doi: 10.1039/c1pp05131h. Epub 2011 Jul 20.
5. The redox antimalarial dihydroartemisinin targets human metastatic melanoma cells but not primary melanocytes with induction of NOXA-dependent apoptosis. Cabello CM, Lamore SD, Bair WB 3rd, Qiao S, Azimian S, Lesson JL, Wondrak GT. Invest New Drugs. 2012 Aug;30(4):1289-301. doi: 10.1007/s10637-011-9676-7. Epub 2011 May 6.
6. Zinc pyrithione impairs zinc homeostasis and upregulates stress response gene expression in reconstructed human epidermis. Lamore SD, Wondrak GT. Biometals. 2011 Oct;24(5):875-90. doi: 10.1007/s10534-011-9441-6. Epub 2011 Mar 22.
7. DCPIP (2,6-dichlorophenolindophenol) as a genotype-directed redox chemotherapeutic targeting NQO1*2 breast carcinoma. Cabello CM, Lamore SD, Bair WB 3rd, Davis AL, Azimian SM, Wondrak GT. Free Radic Res. 2011 Mar;45(3):276-92. doi: 10.3109/10715762.2010.526766. Epub 2010 Nov 1.
8. Proteomic identification of cathepsin B and nucleophosmin as novel UVA-targets in human skin fibroblasts. Lamore SD, Qiao S, Horn D, Wondrak GT. Photochem Photobiol. 2010 Nov-Dec;86(6):1307-17. doi: 10.1111/j.1751-1097.2010.00818.x. Epub 2010 Oct 14.
9. Themalondialdehyde-derived fluorophore DHP-lysine is a potent sensitizer of UVA-induced photooxidative stress in human skin cells. Lamore SD, Azimian S, Horn D, Anglin BL, Uchida K, Cabello CM, Wondrak GT. J Photochem Photobiol B. 2010 Dec 2;101(3):251-64. doi: 10.1016/j.jphotobiol.2010.07.010. Epub 2010 Jul 30.
10. The cinnamon-derived dietary factor cinnamic aldehyde activates the Nrf2-dependent antioxidant response in human epithelial colon cells. Wondrak GT, Villeneuve NF, Lamore SD, Bause AS, Jiang T, Zhang DD. Molecules. 2010 May 7;15(5):3338-55. doi: 10.3390/molecules15053338.
11. Resveratrol prevents epigenetic silencing of BRCA-1 by the aromatic hydrocarbon receptor in human breast cancer cells. Papoutsis AJ, Lamore SD, Wondrak GT, Selmin OI, Romagnolo DF. J Nutr. 2010 Sep;140(9):1607-14. doi: 10.3945/jn.110.123422. Epub 2010 Jul 14.
12. HMGB1-directed drug discovery targeting cutaneous inflammatory dysregulation. Lamore SD, Cabello CM, Wondrak GT. Curr Drug Metab. 2010 Mar;11(3):250-65. Review.
13. The topical antimicrobial zinc pyrithione is a heat shock response inducer that causes DNA damage and PARP-dependent energy crisis in human skin cells. Lamore SD, Cabello CM, Wondrak GT. Cell Stress Chaperones. 2010 May;15(3):309-22. doi: 10.1007/s12192-009-0145-6. Epub 2009 Oct 7.
14. The experimental chemotherapeutic N6-furfuryladenosine (kinetin-riboside) induces rapid ATP depletion, genotoxic stress, and CDKN1A(p21) upregulation in human cancer cell lines. Cabello CM, Bair WB 3rd, Ley S, Lamore SD, Azimian S, Wondrak GT. Biochem Pharmacol. 2009 Apr 1;77(7):1125-38. doi: 10.1016/j.bcp.2008.12.002. Epub 2008 Dec 24.
15. The cinnamon-derived Michael acceptor cinnamic aldehyde impairs melanoma cell proliferation, invasiveness, and tumor growth. Cabello CM, Bair WB 3rd, Lamore SD, Ley S, Bause AS, Azimian S, Wondrak GT. Free Radic Biol Med. 2009 Jan 15;46(2):220-31. doi: 10.1016/j.freeradbiomed.2008.10.025. Epub 2008 Nov 1.
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