Paul Severson, PhD

Pharmacology and Toxicology
Pharmacology and Toxicology
Scientist 1, Translational Pharmacology, Plexxikon
Dissertation Title: 
“The Role of N-Acetyl Transferase in the Mutagenicity of 4-Aminobiphenyl”
Honors and Achievements: 
1. Human Genes and the Environment Research Training Program, 2011-12.
2. NIEHS Training Grant - Environmental Toxicology of Human Diseases, 2012 (32).
1. Severson, P, & Futscher, BW: Epigenomic Actions of Environmental Arsenicals. In: Saura Sahu (ed), Toxicology and Epigenetics. Wiley, 2012. NIHMSID: 578550.
2.  Zhao, F., Severson, P.L., Pacheco, S.M., Futscher, B.W., Klimecki, W.: Arsenic Exposure Induces the Warburg Effect in Cultured Human Cells. Toxicology and Applied Pharmacology, 271(1):72–77, 2013.
3. Severson, P.L., Tokar, E.J., Vrba, L., Waalkes, M.P., Futscher, B.W.: Coordinate H3K9 and DNA methylation silencing of ZNFs in toxicant-induced malignant transformation. Epigenetics, 8(10):1–9, 2013.
4. Clarke, J.D., Novak, P., Lake, A.D., Shipkova, P., Aranibar, N., Robertson, D., Severson, P.L., Reily, M.D., Futscher, B.W., Lehman-McKeeman, L.D., Cherrington, N.J.: Characterization of Hepatocellular Carcinoma Related Genes and Metabolites in Human Nonalcoholic Fatty Liver Disease. Digestive Diseases and Sciences, 59(2):365-74, 2014.
5. Vorrink, S., Severson, P., Kulak, M.V., Futscher, B.W., Domann, F.: Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines. Toxicology and Applied Pharmacology, 274(3):408–16, 2014.
6. Severson, P.L., Vrba, L., Stampfer, M. R., Futscher, B.W.:  Exome-wide Mutation Profile in Benzo[a]pyrene-derived Post-stasis and Immortal Human Mammary Epithelial Cells. Mutation Research - Genetic Toxicology and Environmental Mutagenesis (in press).
Career Type: