Don Kirkpatrick, PhD

I obtained my Ph.D. in Dr. Gandolfi’s lab while studying the effects of low-level arsenic on the ubiquitin-proteasome system. This system regulates numerous cellular processes under normal conditions, plays a key role in protecting cells from toxic insults, and is disrupted in many human diseases. Through my graduate research, I developed an interest in mass spectrometry based proteomics and went on to complete a postdoctoral fellowship in Steve Gygi’s lab at Harvard Medical School. During my time in Boston, I developed new quantitative tools and applied them to continue dissecting the molecular mechanisms of the ubiquitin-proteasome system.
At Genentech, I am a part of the Microchemistry and Proteomics group and continuing to develop new technologies to dissect the molecular basis cancer and immune disease. My group is involved in developing and implementing quantitative, mass spectrometry based approaches to study proteins and post-translational modifications in normal and diseased tissues/cells.
Pharmacology and Toxicology
Pharmacology and Toxicology
Scientist, Genentech Department of Protein Chemistry, South San Francisco, CA
Dissertation Title: 
“The Effects of Arsenic on the Ubiquitin Dependent Proteolytic Pathway”
Career Type: