Alicia Bolt, PhD

My research focused on investigating the mechanism of arsenic-induced immunotoxicity using an in-vitro model of normal human B-cells.  I characterized the role of a novel cell degradation/turnover process, autophagy, in arsenic-induced cellular damage and how disruption of the autophagic process altered normal B-cell function.
I am currently a postdoctoral fellow at McGill University in Montreal Canada investigating the role of the metal tungsten in the development of pre-B acute lymphoblastic leukemia.
Pharmacology and Toxicology
Pharmacology and Toxicology
Postdoctoral Fellow at Lady Davis Institute, McGill University Montreal, Quebec, Canada
Dissertation Title: 
“Arsenite Alters Lysosome-Mediated Degradation and the Autophagy Process Leading to Immunosuppression in Human B-Lymphoblastoid Cell Lines”
1. Bolt AM, Zhao F, Pacheco S, Klimecki WT. 2012. Arsenite-induced autophagy is associated with proteotoxicity in human lymphoblastoid cells. In Review.
2. Bolt AM and Klimecki WT. 2012. Autophagy in Toxicology: Self-consumption in times of stress and plenty. Journal of Appl. Toxicology. Epub 2012 February 15.
3. Bolt AM, Douglas RM, Klimecki WT. 2010. Arsenite exposure in human lymphoblastoid cell lines induces autophagy and coordinated induction of lysosomal genes. Tox Letters: 199 (2): 153-159.
4. Bolt AM, Byrd RM, Klimecki WT. 2010. Autophagy is the predominant process induced by arsenite in human lymphoblastoid cell lines. Toxicol Appl Pharmacol:244 (3): 366-373.
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