Alexandria Lau, PhD

The primary focus of my academic research involved studying the mechanisms associated with arsenic-induced activation of the Nrf2-Keap1 antioxidant pathway, an important signaling pathway responsible for the detoxification and elimination of toxicants and carcinogens. I am currently a research toxicologist at S.C. Johnson at their headquarters in Racine, Wisconsin. I am in the Product Safety Department in the Global Safety Assessment and Regulatory Affairs Division (GSARA) providing regulatory and safety support for pest control.
Pharmacology and Toxicology
Pharmacology and Toxicology
Research Toxicologist S.C. Johnson & Son, Inc. Racine, WI
Dissertation Title: 
“The role of the Nrf2-Keapl Pathway in Autophagy and how it Contributes to Arsenic Carcinogenicity"
Honors and Achievements: 
1. Mentor for undergraduate and graduate students in the laboratory of Dr. Donna D. Zhang, 2007-12.
2. Student Poster Award-3rd Biennial Research Frontiers in Nutritional Sciences Conference, 2009.
3. Student Travel Award- Mountain West Society of Toxicology, 2009.
4. Place Student Oral Platform-Mountain West of toxicology, 2009.
5. Summer Instuctor and Counselor, Tucson and Yuma Pharmacy Camp, 2009-10.
6. Appreciation Award, Mountain West Society of Toxicology, 2010.
7. Caldwell Health Sciences Research Fellowship, 2010.
8. NIEHS Training Grant-Environmental Toxicology of Human Diseases, 2010 (30).
9. Spring and Fall Reviewer, University of Arizona graduate and Professional Student Council Travel Grant Committee, 2010.
10. Co-organizer of the 28th Annual Regional Mountain West Society of Toxicology Meeting in Tucson, Arizona, 2010.
11. Graduate Track Awards: Outstanding Research, 2011-12.
12. Society of Toxicology Graduate Travel Award, 2011.
13. American Association of Chinese in Toxicology SIG Jean Lu Student Scholarship Award, 2011.
14. Women in Toxicology Special Interest Group-Vera W. Hudson and Elizabeth K. Weisburger Student Scholarshop Award, 2011.
15. Society of Toxicology-Novartis Fellowship, 2011.
16. Laboratory Tour Guide for PharmD Candidates, University of Arizona College of Pharmacy, 2011.
17. Presenter for Undergraduate Education Program: Poster Session for Visitng Students at the 50th Anniversary SOT Annual Meeting, 2011.
18. Chairperson for the Oxidative Stress and Redox Biology Poster Session at the 50th Anniversary SOT Annual Meeting, 2011.
19. Student Volunteer for the Society of Toxicology's K-12 Outreach Activity at the 50th Anniversary SOT Annual Meeting, Koshland Science Museum of the National Academy of Science, Washington DC, 2011.
20. SOT Award, First Place, Carl C. Smith Mechanisms Specialty Section, 2012.
1. Bray, K., Mathew, R., Lau, A., Kamphorst, J.J., Fan, J., Chen, H., Stein, M., Kaelin, W.G., DiPaola, R.S., Zhang, D. D., Rabinowitz, J.D., White, E. (2011). Mitophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition. Accepted PLoS One.
2. Lau, A., Tian, W., Whitman, S.A., Zhang, D.D. (2012). The predicted molecular weight of Nrf2: It is what it is not. Antioxidants & Redox Signaling [Epub ahead of print].
3. Chen, W., Jiang, T., Wang, H., Tao, S., Lau, A., Fang, D., Zhang, D.D. (2012). Does Nrf2 contribute to p53-mediated control of cell survival and death? Antioxidants & Redox Signaling [Epub ahead of print].
4. Sun, Z., Wu, T., Zhao, F., Lau, A., Birch, C. M., and Zhang, D. D. (2011). KPNA6 (Importin {alpha}7)-mediated nuclear import of Keap1 represses the Nrf2-dependent antioxidant response. Molecular and Cellular Biology 31, 1800-1811.
5. Ren, D., Villeneuve, N. F., Jiang, T., Wu, T., Lau, A., Toppin, H. A., and Zhang, D. D. (2011). Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Proceedings of the National Academy of Sciences U S A 108, 1433-1438.
6. Villeneuve, N. F., Lau, A., and Zhang, D. D. (2010). Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases. Antioxidant and Redox Signaling 13, 1699-1712.
7. Babic, A., Loftin, I. R., Stanislaw, S., Wang, M., Miller, R., Warren, S. M., Zhang, W., Lau, A., Miller, M., Wu, P., et al. (2010). The impact of pre-analytical processing on staining quality for H&E, dual hapten, dual color in situ hybridization and fluorescent in situ hybridization assays. Methods 52, 287-300.
8. Lau, A., Wang, X. J., Zhao, F., Villeneuve, N. F., Wu, T., Jiang, T., Sun, Z., White, E., and Zhang, D. D. (2010). A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62. Molecular and Cellular Biology 30, 3275-3285.
9. Zhao, F., Wu, T., Lau, A., Jiang, T., Huang, Z., Wang, X. J., Chen, W., Wong, P. K., and Zhang, D. D. (2009). Nrf2 promotes neuronal cell differentiation. Free Radical Biology & Medicine 47, 867-879.
10. Lau, A., Villeneuve, N. F., Sun, Z., Wong, P. K., and Zhang, D. D. (2008). Dual roles of Nrf2 in cancer. Pharmacological Research 58, 262-270.
11. Finnerty, K., Choi, J. E., Lau, A., Davis-Gorman, G., Diven, C., Seaver, N., Linak, W. P., Witten, M., and McDonagh, P. F. (2007). Instillation of coarse ash particulate matter and lipopolysaccharide produces a systemic inflammatory response in mice. Journal of Toxicology and Environmental Health Part A 70, 1957-1966.
Career Type: