Pharmacology and Toxicology Department Highlights: March 2026
April 1, 2026
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Publications
Christopher Hulme
Seekins CA, Okine M, Forrest EG, Chavez T, Stump A, Kaleeswaran V, Carr JE, Hulme C, Cardenas P, Vanderah TW, Streicher JM, Cartmell C. Barettin, a Nonopioid, Nonhallucinogenic Marine Natural Product with Antihyperalgesic Properties Mediated by 5HT2A Inverse Agonism. J Nat Prod. 2026 Mar 31. doi: 10.1021/acs.jnatprod.6c00169. Epub ahead of print. PMID: 41914263.
Nathan Cherrington
Farrera DO, Maloney MM, LaMadrid CS, Lenzen-Hammerel P, Radtke LR, Cherrington NJ. Detection and quantification of ezetimibe and its major glucuronide in patients with hepatic impairment via liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2026 Aug 1;275:117455. doi: 10.1016/j.jpba.2026.117455. Epub 2026 Mar 9. PMID: 41818831.
Farrera DO, Maloney MM, LaMadrid CS, Lenzen-Hammerel P, Radtke LR, Cherrington NJ. Detection and quantification of ezetimibe and its major glucuronide in patients with hepatic impairment via liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2026 Aug 1;275:117455. doi: 10.1016/j.jpba.2026.117455. Epub 2026 Mar 9. PMID: 41818831.
Abhijit Date
Shingade K, Sutar Y, Annaji M, Kulkarni M, Date AA. Borneol-caprylic acid deep eutectic solvent (DES) based microemulsion gel for improved topical delivery of ivermectin. Int J Pharm. 2026 Mar 28;696:126819. doi: 10.1016/j.ijpharm.2026.126819. Epub ahead of print. PMID: 41912014.
Shingade K, Sutar Y, Annaji M, Kulkarni M, Date AA. Borneol-caprylic acid deep eutectic solvent (DES) based microemulsion gel for improved topical delivery of ivermectin. Int J Pharm. 2026 Mar 28;696:126819. doi: 10.1016/j.ijpharm.2026.126819. Epub ahead of print. PMID: 41912014.
Qing-Yu Zhang, Weiguo Han, Xinxin Ding
Tran LM, Edwards PC, Yang W, Zhang QY, Han W, Kovalchuk N, Ding L, Wu X, Fan X, Arredondo A, Merluza RJA, Besselsen DG, Reader JR, Van Winkle LS, Ding X. Role of P450 enzymes of the Cyp2abfgs gene subfamilies in tobacco smoke-induced lung tumorigenesis in mice. Carcinogenesis. 2026 Mar 19:bgag017. doi: 10.1093/carcin/bgag017. Epub ahead of print. PMID: 41855137.
Tran LM, Edwards PC, Yang W, Zhang QY, Han W, Kovalchuk N, Ding L, Wu X, Fan X, Arredondo A, Merluza RJA, Besselsen DG, Reader JR, Van Winkle LS, Ding X. Role of P450 enzymes of the Cyp2abfgs gene subfamilies in tobacco smoke-induced lung tumorigenesis in mice. Carcinogenesis. 2026 Mar 19:bgag017. doi: 10.1093/carcin/bgag017. Epub ahead of print. PMID: 41855137.
Gregory Thatcher, Rui Xiong
Gannarapu MR, Indukuri D, Holberg C, Ratia K, Ramos OL, Cardoza S, Velma GR, Musku SR, Qi Z, Slilaty S, Li Z, Rong L, Thatcher GRJ, Xiong R. Discovery of the SARS-CoV-2 Papain-Like Protease Inhibitor MR1-114: From Structure-Based Design to In Vivo Antiviral Efficacy. J Med Chem. 2026 Mar 26. doi: 10.1021/acs.jmedchem.5c03846. Epub ahead of print. PMID: 41886743.
Gannarapu MR, Indukuri D, Holberg C, Ratia K, Ramos OL, Cardoza S, Velma GR, Musku SR, Qi Z, Slilaty S, Li Z, Rong L, Thatcher GRJ, Xiong R. Discovery of the SARS-CoV-2 Papain-Like Protease Inhibitor MR1-114: From Structure-Based Design to In Vivo Antiviral Efficacy. J Med Chem. 2026 Mar 26. doi: 10.1021/acs.jmedchem.5c03846. Epub ahead of print. PMID: 41886743.
Rick Schnellmann
McAlister KW, Scholpa NE, Thompson AD, Janda J, Girdhar I, Doyle KP, Sutphin GL, Schnellmann RG. 5-Hydroxytryptamine 2B receptor antagonism restores ATP and reduces tubulointerstitial fibrosis in the renal cortices of aged mice. J Pharmacol Exp Ther. 2026 Mar 23;393(5):104321. doi: 10.1016/j.jpet.2026.104321. Epub ahead of print. PMID: 42000396.
McAlister KW, Scholpa NE, Thompson AD, Janda J, Girdhar I, Doyle KP, Sutphin GL, Schnellmann RG. 5-Hydroxytryptamine 2B receptor antagonism restores ATP and reduces tubulointerstitial fibrosis in the renal cortices of aged mice. J Pharmacol Exp Ther. 2026 Mar 23;393(5):104321. doi: 10.1016/j.jpet.2026.104321. Epub ahead of print. PMID: 42000396.