Pharmacology and Toxicology Department Highlights: June 2026
July 1, 2026
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Publications
Seekins CA, Archuleta MR, Evans AE, Podgorski J, Carr JE, Kaleeswaran V, Nguyen KB, Flowers ME, Hulme C, Vanderah TW, Cárdenas P, Streicher JM, Lee NY, Cartmell C. Barettin Suppresses Pancreatic Ductal Adenocarcinoma Proliferation via Topoisomerase IIα Inhibition. Mar Drugs. 2026 Jun 7;24(6):201. doi: 10.3390/md24060201. PMID: 42346787; PMCID: PMC13302744.
Vallorz EL, Cleveland K, Scholpa NE, Mansour HM, Schnellmann J, Schnellmann RG. Kidney-Targeted Nanoparticle Delivery of Formoterol Mitigates Diabetic Kidney Disease without Adverse Cardiac Effects. ACS Pharmacol Transl Sci. 2026 May 1;9(6):1426-1438. doi: 10.1021/acsptsci.6c00009. PMID: 42312166; PMCID: PMC13270454.
Kumar SS, Chapman ED, Becktel DA, Whitman SA, Crumpacker R, Zbesko JC, Berchtold D, Dames C, Cuartero MI, Garcia-Culebras A, Hegarty LM, Brezzo G, Goertz JE, Zera K, Smith CJ, Allan SM, Meisel C, Meisel A, Moro MÁ, McColl BW, Anrather J, Buckwalter MS, Morrison HW, Schnellmann RG, Doyle KP. Infarct-associated oligoclonal T cell expansion in chronic experimental stroke across age, sex, and models. Exp Neurol. 2026 Jun 12;404:115878. doi: 10.1016/j.expneurol.2026.115878. Epub ahead of print. PMID: 42285250; PMCID: PMC13317935.
Nowar R, Velma GR, Fu J, Kidwai A, Bauc G, Ackerman-Berrier M, Thatcher GRJ, Brady ST, Ben Aissa M. Inhibition of pathogenic tau signaling via blocking of the phosphatase-activating domain by novel small molecules. Front Pharmacol. 2026 Jun 10;17:1829420. doi: 10.3389/fphar.2026.1829420. PMID: 42358353; PMCID: PMC13291570.
Laham MS, Ackerman-Berrier MS, Alam F, Turner S, Velma GR, Penton C, Musku SR, Rana M, Thulasingam S, Annadurai A, Sulaiman MI, Ma N, Thatcher GRJ. Exploration of precision coregulator TR-FRET identifies diverse signatures for LXR ligands relevant to discovery of nonlipogenic ABCA1 inducers. Elife. 2026 Jun 22;14:RP109146. doi: 10.7554/eLife.109146. PMID: 42325211; PMCID: PMC13286573.
Velma GR, Kumar S, Srivastava P, Misra S, Sathish Nair R, Musku SR, Ackerman-Berrier M, Singh SK, Vyas H, Alves ETM, Rana B, Xiong R, Bloem L, Rana A, Thatcher GRJ. Mixed Lineage Kinase Suppression in Triple-Negative Breast Cancer: Identification of a Dual Inhibitor Targeting MLK3 and NAMPT. J Med Chem. 2026 Jun 25;69(12):14191-14212. doi: 10.1021/acs.jmedchem.5c03558. Epub 2026 Jun 10. PMID: 42269602.
Velma GR, Kumar S, Srivastava P, Misra S, Sathish Nair R, Musku SR, Ackerman-Berrier M, Singh SK, Vyas H, Alves ETM, Rana B, Xiong R, Bloem L, Rana A, Thatcher GRJ. Mixed Lineage Kinase Suppression in Triple-Negative Breast Cancer: Identification of a Dual Inhibitor Targeting MLK3 and NAMPT. J Med Chem. 2026 Jun 25;69(12):14191-14212. doi: 10.1021/acs.jmedchem.5c03558. Epub 2026 Jun 10. PMID: 42269602.
Wei R, Pokhrel R, Stratton D, Centuori S, Curiel-Lewandrowski C, Wondrak GT, Dickinson SE, LaFleur BJ, Sun X. Single-Cell Transcriptomic Mapping of PD-L1/TLR4 Remodeling Informs Topical Immunoprevention Timing in Skin Carcinogenesis. bioRxiv [Preprint]. 2026 Jun 4:2026.06.01.729458. doi: 10.64898/2026.06.01.729458. PMID: 42282577; PMCID: PMC13251948.
Wang Q, Khan AU, Hu C, Petricoin EF, Morris R, Dickinson SE, Wondrak GT, Liu L, Bode AM, Goldfarb NI, Curiel-Lewandrowski C, Zhang T. CD70 drives cSCC growth by linking DNA damage response, inflammation, and tumor-stromal signaling. Cell Death Dis. 2026 Jun 11. doi: 10.1038/s41419-026-08876-x. Epub ahead of print. PMID: 42270581.
Tran, L. M., Edward, P. C., Yang, W., Zhang, Q.-Y., Han, W., Kovalchuk, N., Ding, L., Wu, X., Fan, X., Arredondo, A., Merluza, R. J., Reader, J. R., Besselsen, D. G., Van Winkle, L. S., and Ding, X.: Role of P450 enzymes of the Cyp2abfgs gene subfamilies in tobacco smoke-induced lung tumorigenesis in mice. Carcinogenesis.
Tran, L. M., Edward, P. C., Yang, W., Zhang, Q.-Y., Han, W., Kovalchuk, N., Ding, L., Wu, X., Fan, X., Arredondo, A., Merluza, R. J., Reader, J. R., Besselsen, D. G., Van Winkle, L. S., and Ding, X.: Role of P450 enzymes of the Cyp2abfgs gene subfamilies in tobacco smoke-induced lung tumorigenesis in mice. Carcinogenesis.