Pharmacology and Toxicology Department Highlights: March 2021

(March 1, 2021)

Publications

Potent, Novel SARS-CoV-2 PLpro Inhibitors Block Viral Replication in Monkey and Human Cell Cultures. BioRxiv. 2021.02.13.431008.

  • Shen, Z.
  • Ratia, K.
  • Cooper, L.
  • Kong, D.
  • Lee, H
  • Kwon, Y.
  • Li, Y
  • Alqarni, S.
  • Huang, F.
  • Dubrovskyi, O.
  • Rong, L.
  • Gregory Thatcher, PhD
  • Xiong, R.

Extending the Calpain–Cathepsin Hypothesis to the Neurovasculature: Protection of Brain Endothelial Cells and Mice from Neurotrauma ACS Pharmacol. Transl. Sci. 2021, 4, 1, 372–385.

Evidence for distinct mechanisms of small molecule inhibitors of filovirus entry Plos Pathogens. 2021 Feb 4;17(2):e1009312.

  • Schafer, A.
  • Xiong, R.
  • Cooper, L.
  • Nowar, R.
  • Lee, H.
  • Li, Y.
  • Ramirez, B.
  • Peet, N.
  • Caffrey, M.
  • Gregory Thatcher, PhD
  • Saphire, E.
  • Cheng, H.
  • Rong, L.

Comparison of L-Carnitine and L-Carnitine HCL Salt for Targeted Lung Treatment of Pulmonary Hypertension (PH) as Inhalation Aerosols: Design, Comprehensive Characterization, In Vitro 2D/3D Human Lung Cell Cultures, and In Vivo MCT-Rat Model of PH. Pulm Pharmacol Ther. 2021 Feb 5:101998. 

  • Acosta, M.
  • Muralidhran, P.
  • Abrahamson, M.
  • Grijalva, C.
  • Carver, M.
  • Tang, H.
  • Klinger, C.
  • Fineman, J.
  • Black, S.
  • Heidi Mansour, PhD, RPh