Pharmacology and Toxicology Department Highlights: December 2020

(December 1, 2020)

Publications

Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against M pro and cathepsin L. Sci Adv. 2020 Nov 6:eabe0751. Online ahead of print. PMID: 33158912

  • Sacco, MD.
  • Ma, C.
  • Lagarias, P.
  • Gao, A.
  • Townsend, JA.
  • Meng, X.
  • Dube, P.
  • Zhang, X.
  • Hu, Y.
  • Kitamura, N.
  • Hurst, B.
  • Tarbet, B.
  • Marty, MT.
  • Kolocouris, A.
  • Xiang, Y.
  • Chen, Y.
  • Jun Wang, PHD

Ebselen, disulfiram, carmofur, PX-12, tideglusib, and shikonin are non-specific promiscuous SARS-CoV-2 main protease inhibitorsACS Pharmacol. Transl. Sci. ASAP.

  • Ma, C.
  • Hu, Y.
  • Townsend, J.
  • Lagarias, P.
  • Marty, M.
  • Kolocouris, A.
  • Jun Wang, PHD

Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main proteaseCell Res. 2020 Aug;30(8):678-692. Epub 2020 Jun 15. PMID: 32541865

  • Ma, C.
  • Sacco, MD.
  • Hurst, B.
  • Townsend, JA.
  • Hu, Y.
  • Szeto, T.
  • Zhang, X.
  • Tarbet, B.
  • Marty, MT.
  • Chen, Y.
  • Jun Wang, PHD

Chemical Probes for Blocking of Influenza A M2 Wild-type and S31N ChannelACS Chem. Biol. 2020 Sep 18;15(9):2331-2337. Epub 2020 Aug 27. PMID: 32786258.

  • Tzitzoglaki, C.
  • McGuire, K.
  • Lagarias, P.
  • Konstantinidi, A.
  • Hoffmann, A.
  • Fokina, NA.
  • Ma, C.
  • Papanastasiou, I.
  • Schreiner, PR.
  • Vázquez, S.
  • Schmidtke, M.
  • Jun Wang, PHD
  • Busath, DD.
  • Kolocouri, A.

Crosstalk Between Obstructive Sleep Apnea and Comorbid Hypertension, Remodeling, and Ischemic Stroke; Matrix Metalloproteinase-9 as a Messenger. Journal of Clinical Sleep Medicine (2020) Oct 27. PMID: 33108267

Advanced Spray-Dried Proliposomes of Amphotericin B as Microparticles/Nanoparticles as Dry Powder Inhalers for Targeted Pulmonary Drug Delivery. Pulmonary Pharmacology & Therapeutics (2020) Oct 31;64:101975. PMID: 33137515

Design and Development of Innovative Microparticulate/Nanoparticulate Inhalable Dry Powders of a Novel Synthetic Trifluorinated Chalcone Derivative and Nrf2 Agonist. Scientific Reports (2020) 10(1):19771. PMID: 33188247

Inhalable Nanoparticles/Microparticles of an AMPK and Nrf2 Activator for Targeted Pulmonary Drug Delivery as Dry Powder Inhalers. The AAPS Journal: Special Theme Issue: Celebrating Women in the Pharmaceutical Sciences (2021) 23: Article 2.

Advanced Nanoparticle/Microparticle Dual-Drug Combination Lactose Carrier-Free Dry Powder Inhalation Aerosols. RSC Advances (2020) 10: 41846-41856.

 


Kudos

HEIDI MANSOUR, PHD, RPH

Jun Wang, PHD