Pharmacology and Toxicology Department Highlights: September 2019

(September 1, 2019)

Publications

Non-covalent NRF2 Activation Confers Greater Cellular Protection than Covalent Activation. Cell Chem Biol. 2019 Aug 7. pii: S2451-9456(19)30242-9. doi: 10.1016/j.chembiol.2019.07.011. [Epub ahead of print]

Filtering through the role of NRF2 in kidney disease. Arch Pharm Res. 2019 Aug 1. doi: 10.1007/s12272-019-01177-2. [Epub ahead of print]

An Isoform-Selective PTP1B Inhibitor Derived from Nitrogen-Atom Augmentation of Radicicol. Biochemistry. 2019 Jul 30;58(30):3225-3231. doi: 10.1021/acs.biochem.9b00499. Epub 2019 Jul 18.

  • Donna Zhang, PhD
  • Eli Chapman, PhD
  • Shi, T
  • Wijeratne, EMK
  • Solano, C
  • Ambrose, AJ
  • Ross, AB
  • Norwood, C
  • Orido, CK
  • Grigoryan, T
  • Tillotson, J
  • Kang, M
  • Luo, G
  • Keegan, BM
  • Hu, W
  • Blagg, BSJ
  • Gunatilaka, AAL

A high throughput substrate binding assay reveals hexachlorophene as an inhibitor of the ER-resident HSP70 chaperone GRP78. Bioorg Med Chem Lett. 2019 Jul 15;29(14):1689-1693. doi: 10.1016/j.bmcl.2019.05.041. Epub 2019 May 20.

Genome-Wide CRISPR Screen Reveals Autophagy Disruption as the Convergence Mechanism That Regulates the NRF2 Transcription Factor. Mol Cell Biol. 2019 Jun 13;39(13). pii: e00037-19. doi: 10.1128/MCB.00037-19. Print 2019 Jul 1.

Spermidine Confers Liver Protection by Enhancing NRF2 Signaling Through a MAP1S-Mediated Noncanonical Mechanism. Hepatology. 2019 Jul;70(1):372-388. doi: 10.1002/hep.30616. Epub 2019 May 20.

Presentations

Donna Zhang, PhD

Heidi Mansour, PhD, RPh