Hope Center Researchers Collaborate with UA Cancer Center

(March 22, 2019) UA College of Pharmacy faculty, graduate students, and fellows recently collaborated with colleagues from the UA CANCER CENTER to publish an article in the Journal of Thrombosis and Thrombolysis evaluating the safety and efficacy of direct oral anticoagulants (DOACs) in patients with cancer. The study, titled DIRECT ORAL ANTICOAGULANTS FOR THE TREATMENT OF VENOUS THROMBOEMBOLISM IN PATIENTS WITH ACTIVE MALIGNANCY: A SYSTEMATIC REVIEW AND META-ANALYSIS was conducted as part of the HOPE Center’s Clinical Research in Human Therapeutics Fellowship Program. The research team conducted a meta-analysis that included eight studies identified in their comprehensive literature search. Results suggest that DOACs might reduce the incidence of venous thromboembolism in cancer patients without putting them at high risk for bleeding events. Authors noted that future studies are necessary to assess efficacy and safety of DOACs in patients with different cancers.

This study represents a successful collaboration of HOPE CENTER faculty, graduate students, and fellows with other health sciences colleagues. Authors include:

Al Yami MS, McBride A, Katragadda C, Martin JR, Badreldin HA, Mohammed AH, Elmubark AM, Alzahrani MY, Alsheri AM, Abraham I. Direct oral anticoagulants for the treatment of venous thromboembolism in patients with active malignancy: a systematic review and meta-analysis. J Thromb Thrombolysis (2019) 47: 166. DOI: 10.1007/s11239-018-1777-0. PMID: 30478721