Xinxin Ding, PhD

Department Head, Pharmacology and Toxicology
Professor, Pharmacology & Toxicology
Professor, BIO5 Institute
Member, University of Arizona Cancer Center
Member, Southwest Environmental Health Sciences Center
R. Ken and Donna Coit Professorship in Drug Discovery

Xinxin Ding, PhD, department head, Pharmacology and Toxicology, College of Pharmacy—studies enzyme function, regulation and genetics as applied to translational research for drug safety and efficacy and genetic and environmental risks for chemical toxicity.

Author of nearly 200 peer-reviewed papers, book chapters and articles for “Drug Metabolism and Disposition,” Grants from the National Cancer Institute and National Institute of Environmental Health Sciences of the National Institutes of Health fund his work, in part. Former chair of the NIH XNDA study section (2016-2018), he chaired (2018-19) the Drug Metabolism and Disposition Division of the American Society for Pharmacology and Experimental Therapeutics.

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Education & Post Graduate Training: 

PhD, Biological Chemistry, Medical School, University of Michigan, 1988
BS, Biology (Medical Physiology), Nanjing University (Nanjing, China), 1982

Areas of Research: 

Drug metabolism/disposition
Enzyme function/regulation
Drug safety/efficacy
Genetic/environmental risks for chemical toxicity

Types of Research: 
Laboratory-based Research
Professional Organizations: 

American Society for Biochemistry and Molecular Biology, member (1988-Present)
International Society for the Study of Xenobiotics, Member (1993-Present)
Society of Toxicology, Member (1995-Present)
American Society for Pharmacology and Experimental Therapeutics, Member (1997-Present)
American Association for Cancer Research, member (2004-Present)

Select Publications


Conroy JL, Fang C, Gu J, et al. "Opioids activate brain analgesic circuits through cytochrome P450/epoxygenase signaling." Nat. Neurosci.. 2010;13(3):284-6. PMCID: PMC2828325  PMID: 20139973


Weng Y, Fang C, Turesky RJ, Behr M, Kaminsky LS, Ding X. "Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice." Cancer Res.. 2007;67(16):7825-32. PMID: 17699788


Gu J, Weng Y, Zhang Q-Y, et al. "Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase." J. Biol. Chem.. 2003;278(28):25895-901. PMID: 12697746


Su T, Bao Z, Zhang QY, Smith TJ, Hong JY, Ding X. "Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone." Cancer Res.. 2000;60(18):5074-9. PMID: 11016631