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Xinxin Ding, PhD

Department Head, Pharmacology and Toxicology
Professor, Pharmacology & Toxicology
Professor, BIO5 Institute
Member, University of Arizona Cancer Center
Member, Southwest Environmental Health Sciences Center
R. Ken and Donna Coit Professorship in Drug Discovery

Xinxin Ding, PhD, department head, Pharmacology and Toxicology, College of Pharmacy—studies enzyme function, regulation and genetics as applied to translational research for drug safety and efficacy and genetic and environmental risks for chemical toxicity.

Author of nearly 200 peer-reviewed papers, book chapters and articles for “Drug Metabolism and Disposition,” Grants from the National Cancer Institute and National Institute of Environmental Health Sciences of the National Institutes of Health fund his work, in part. Former chair of the NIH XNDA study section (2016-2018), he chaired (2018-19) the Drug Metabolism and Disposition Division of the American Society for Pharmacology and Experimental Therapeutics.

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Education & Post Graduate Training: 

PhD, Biological Chemistry, Medical School, University of Michigan, 1988
BS, Biology (Medical Physiology), Nanjing University (Nanjing, China), 1982

Areas of Research: 

Drug metabolism/disposition
Enzyme function/regulation
Drug safety/efficacy
Genetic/environmental risks for chemical toxicity

Types of Research: 
Laboratory-based Research
Professional Organizations: 

American Society for Biochemistry and Molecular Biology, member (1988-Present)
International Society for the Study of Xenobiotics, Member (1993-Present)
Society of Toxicology, Member (1995-Present)
American Society for Pharmacology and Experimental Therapeutics, Member (1997-Present)
American Association for Cancer Research, member (2004-Present)

Select Publications

2021

Lopez M, Malacarne PF, Gajos-Draus A, et al. "Vascular biotransformation of organic nitrates is independent of cytochrome P450 monooxygenases." Br J Pharmacol. 2021;178(7):1495-1506. PMID: 33450066

2020

Leonardi A, Kovalchuk N, Yin L, et al. "The epitranscriptomic writer ALKBH8 drives tolerance and protects mouse lungs from the environmental pollutant naphthalene." Epigenetics. 2020;15(10):1121-1138. PMCID: PMC7518688  PMID: 32303148
Kovalchuk N, Zhang Q-Y, Van Winkle L, Ding X. "Contribution of Pulmonary CYP-mediated Bioactivation of Naphthalene to Airway Epithelial Injury in the Lung." Toxicol Sci. 2020;177(2):334-346. PMCID: PMC7548286  PMID: 32974682
Ding L, Li L, Liu S, et al. "Proximal Tubular Vacuolization and Hypersensitivity to Drug-Induced Nephrotoxicity in Male Mice With Decreased Expression of the NADPH-Cytochrome P450 Reductase." Toxicol Sci. 2020;173(2):362-372. PMCID: PMC8000068  PMID: 31693140
Lyu Q, Wang H, Kang Y, et al. "RNA-Seq Reveals Sub-Zones in Mouse Adrenal Zona Fasciculata and the Sexually Dimorphic Responses to Thyroid Hormone." Endocrinology. 2020;161(9). PMCID: PMC7446775  PMID: 32697836
He Y., Lian W., Ding L., et al. "Lung injury induced by pyrrolizidine alkaloids depends on metabolism by hepatic cytochrome P450s and blood transport of reactive metabolites.". 2020.

2019

Carratt SA, Hartog M, Buchholz BA, et al. "Naphthalene genotoxicity: DNA adducts in primate and mouse airway explants." Toxicol Lett. 2019;305:103-109. PMCID: PMC6459408  PMID: 30684585
Carratt SA, Kovalchuk N, Ding X, Van Winkle LS. "Metabolism and Lung Toxicity of Inhaled Naphthalene: Effects of Postnatal Age and Sex." Toxicol Sci. 2019;170(2):536-548. PMCID: PMC6657577  PMID: 31020322
Kovalchuk N, Zhang Q-Y, Kelty J, Van Winkle L, Ding X. "Toxicokinetic Interaction between Hepatic Disposition and Pulmonary Bioactivation of Inhaled Naphthalene Studied Using -Null and CYP2A13/2F1-Humanized Mice with Deficient Hepatic Cytochrome P450 Activity." Drug Metab Dispos. 2019;47(12):1469-1478. PMCID: PMC7042723  PMID: 31594800

2017

Li L, Carratt S, Hartog M, et al. "Human CYP2A13 and CYP2F1 Mediate Naphthalene Toxicity in the Lung and Nasal Mucosa of CYP2A13/2F1-Humanized Mice." Environ. Health Perspect.. 2017;125(6):067004. PMCID: PMC5743450  PMID: 28599267