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Xinxin Ding, PhD

Department Head, Pharmacology and Toxicology
Professor, Pharmacology & Toxicology

Xinxin Ding, PhD, department head, Pharmacology and Toxicology, College of Pharmacy—studies enzyme function, regulation and genetics as applied to translational research for drug safety and efficacy and genetic and environmental risks for chemical toxicity.

Author of nearly 200 peer-reviewed papers, book chapters and articles, he serves as associate editor for “Drug Metabolism and Disposition” and “Acta Pharmaceutica Sinica B.” Grants from the National Cancer Institute and National Institute of Environmental Health Sciences of the National Institutes of Health fund his work, in part. Former chair of the NIH XNDA study section (2016-2018), he currently chairs (2018-19) Drug Metabolism and Disposition Division of the American Society for Pharmacology and Experimental Therapeutics.

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Research Interests: 
  • Drug metabolism/disposition
  • Enzyme function/regulation
  • Drug safety/efficacy
  • Genetic/environmental risks for chemical toxicity
Education: 

PhD, Biological Chemistry, Medical School, University of Michigan, 1988
BS, Biology (Medical Physiology), Nanjing University (Nanjing, China), 1982

Select Publications

2017

Li, L., S. Carratt, M. Hartog, N. Kovalchik, K. Jia, Y. Wang, Q-Y. Zhang, P. Edwards, L. Van Winkle, and X. Ding, "Human CYP2A13 and CYP2F1 Mediate Naphthalene Toxicity in the Lung and Nasal Mucosa of CYP2A13/2F1-Humanized Mice.", Environ Health Perspect, vol. 125, issue 6, pp. 067004, 2017 06 08. PMCID: PMC5743450  PMID: 28599267
Li, L., X. Bao, Q-Y. Zhang, M. Negishi, and X. Ding, "Role of CYP2B in Phenobarbital-Induced Hepatocyte Proliferation in Mice.", Drug Metab Dispos, vol. 45, issue 8, pp. 977-981, 2017 Aug. PMCID: PMC5518717  PMID: 28546505
Fasullo, M., J. Freedland, N. St John, C. Cera, P. Egner, M. Hartog, and X. Ding, "An in vitro system for measuring genotoxicity mediated by human CYP3A4 in Saccharomyces cerevisiae.", Environ Mol Mutagen, vol. 58, issue 4, pp. 217-227, 2017 05. PMCID: PMC5479318  PMID: 28436563
Guan, X., M. Qin, Y. Zhang, Y. Wang, B. Shen, Z. Ren, X. Ding, W. Dai, and Y. Jiang, "Safety and Efficacy of Megakaryocytes Induced from Hematopoietic Stem Cells in Murine and Nonhuman Primate Models.", Stem Cells Transl Med, vol. 6, issue 3, pp. 897-909, 2017 Mar. PMCID: PMC5442772 
Wang, L., X. Guan, H. Wang, B. Shen, Y. Zhang, Z. Ren, Y. Ma, X. Ding, and Y. Jiang, "A small-molecule/cytokine combination enhances hematopoietic stem cell proliferation via inhibition of cell differentiation.", Stem Cell Res Ther, vol. 8, issue 1, pp. 169, 2017 Jul 18. PMCID: PMC5516306 
Kovalchuk, N., J. Kelty, L. Li, M. Hartog, Q-Y. Zhang, P. Edwards, L. Van Winkle, and X. Ding, "Impact of hepatic P450-mediated biotransformation on the disposition and respiratory tract toxicity of inhaled naphthalene.", Toxicol Appl Pharmacol, vol. 329, pp. 1-8, 2017 08 15.