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Xinxin Ding, PhD

Department Head, Pharmacology and Toxicology
Professor, Pharmacology & Toxicology
Professor, BIO5 Institute
Professor, Cancer Biology Program
Member, University of Arizona Cancer Center
Member, Southwest Environmental Health Sciences Center
R. Ken and Donna Coit Professorship in Drug Discovery

Xinxin Ding, PhD, department head, Pharmacology and Toxicology, College of Pharmacy—studies enzyme function, regulation and genetics as applied to translational research for drug safety and efficacy and genetic and environmental risks for chemical toxicity.

Author of over 200 peer-reviewed papers, book chapters and articles, Dr. Ding is the Editor-in-Chief (2021-) of “DRUG METABOLISM AND DISPOSITION,” and Secretary/Treasurer (2022-2025) of the AMERICAN SOCIETY FOR PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. With grants from the NATIONAL CANCER INSTITUTE and NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES of the NATIONAL INSTITUTES OF HEALTH, his laboratory studies how drugs and environmental pollutants damage various organs and cause cancer and other diseases. Utilizing analytic-chemical, biochemical, molecular, pharmacological, and toxicological tools, they explore drug- or toxicant-induced changes in the genome, epigenome, and metabolome of genetically engineered or “humanized” animal models. Their main research goals are to identify factors that predispose individuals to chemical toxicity and develop novel approaches for disease prevention.

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Education & Post Graduate Training: 

PhD, Biological Chemistry, Medical School, University of Michigan, 1988
BS, Biology (Medical Physiology), Nanjing University (Nanjing, China), 1982

Areas of Research: 

Drug metabolism/disposition
Enzyme function/regulation
Drug safety/efficacy
Genetic/environmental risks for chemical toxicity

Types of Research: 
Laboratory-based Research
Professional Organizations: 

American Society for Biochemistry and Molecular Biology, member (1988-Present)
International Society for the Study of Xenobiotics, Member (1993-Present)
Society of Toxicology, Member (1995-Present)
American Society for Pharmacology and Experimental Therapeutics, Member (1997-Present)
American Association for Cancer Research, member (2004-Present)

Select Publications

2023

Ding X, Han J, Van Winkle LS, Zhang Q-Y. "Detection of Transgene Location in the CYP2A13/2B6/2F1-transgenic Mouse Model using Optical Genome Mapping Technology." Drug Metab Dispos. 2023;51(1):46-53. PMCID: PMC9832375  PMID: 36273825

2022

Kovalchuk N, Jilek JL, Van Winkle LS, Cherrington NJ, Ding X. "Role of Lung P450 Oxidoreductase in Paraquat-Induced Collagen Deposition in the Lung." Antioxidants (Basel). 2022;11(2). PMCID: PMC8868258  PMID: 35204102
Lai Y, Chu X, Di L, et al. "Recent advances in the translation of drug metabolism and pharmacokinetics science for drug discovery and development." Acta Pharm Sin B. 2022;12(6):2751-2777. PMCID: PMC9214059  PMID: 35755285
Lehmler H-J, Uwimana E, Dean LE, Kovalchuk N, Zhang Q-Y, Ding X. "Probing the Role of CYP2 Enzymes in the Atropselective Metabolism of Polychlorinated Biphenyls Using Liver Microsomes from Transgenic Mouse Models." Chem Res Toxicol. 2022;35(12):2310-2323. PMCID: PMC9957597  PMID: 36473170
Li H, Fan X, Wu X, et al. "Differential Effects of Arsenic in Drinking Water on Mouse Hepatic and Intestinal Heme Oxygenase-1 Expression." Antioxidants (Basel). 2022;11(9). PMCID: PMC9495312  PMID: 36139908
Zhang C-Y, Li X, Stietz KPKeil, et al. "Machine Learning-Assisted Identification and Quantification of Hydroxylated Metabolites of Polychlorinated Biphenyls in Animal Samples." Environ Sci Technol. 2022;56(18):13169-13178. PMCID: PMC9573770  PMID: 36047920
Malacarne PFelipe, Ratiu C, Gajos-Draus A, et al. "Loss of Endothelial Cytochrome P450 Reductase Induces Vascular Dysfunction in Mice." Hypertension. 2022;79(6):1216-1226. PMID: 35354305
Zhou H, Gao F, Yang X, et al. "Endothelial BACE1 Impairs Cerebral Small Vessels via Tight Junctions and eNOS." Circ Res. 2022;130(9):1321-1341. PMID: 35382554
Hannon SL, Ding X. "Assessing cytochrome P450 function using genetically engineered mouse models." Adv Pharmacol. 2022;95:253-284. PMID: 35953157
Kelty J, Kovalchuk N, Uwimana E, Yin L, Ding X, Van Winkle L. "In vitro airway models from mice, rhesus macaques, and humans maintain species differences in xenobiotic metabolism and cellular responses to naphthalene." Am J Physiol Lung Cell Mol Physiol. 2022;323(3):L308-L328. PMCID: PMC9423729  PMID: 35853015