Xinglong Wang, PhD

R. Ken and Donna Coit Endowed Chair in Aging and Neurodegenerative Diseases

Alzheimer’s disease is the most prevalent form of dementia characterized by neuronal loss in the neocortex and hippocampus. Parkinson's disease is the second most common neurodegenerative disease after Alzheimer's disease due to the progressive loss of dopaminergic neurons in the substantia nigra. Frontotemporal dementia is the second most common form of early-onset dementia caused by neuronal loss in the frontal and temporal cortex. Amyotrophic lateral sclerosis is the most common motor disease characterized by progressive motor neuron degeneration in brain stem and spinal cord. My research interest is to understand the mechanism(s) underlying neuronal death in various major neurodegenerative diseases with a focus on Alzheimer’s disease, Parkinson's disease, Frontotemporal dementia, and Amyotrophic lateral sclerosis.

Education & Post Graduate Training: 

Ph.D., Pathology, Case Western Reserve University, Cleveland, 2009

Areas of Research: 
  • Alzheimer’s disease
  • Parkinson's disease
  • Frontotemporal dementia
  • Amyotrophic lateral sclerosis
  • Mitochondrial dysfunction
  • Liquid–liquid phase separation
  • Protein aggregation

Select Publications


Gao J, Wang L, Ren X, et al. "Translational regulation in the brain by TDP-43 phase separation." J Cell Biol. 2021;220(10). PMCID: PMC8404466  PMID: 34427634


Yan T, Liang J, Gao J, et al. "FAM222A encodes a protein which accumulates in plaques in Alzheimer's disease." Nat Commun. 2020;11(1):411. PMCID: PMC6972869  PMID: 31964863
Harland M, Torres S, Liu J, Wang X. "Neuronal Mitochondria Modulation of LPS-Induced Neuroinflammation." J Neurosci. 2020;40(8):1756-1765. PMCID: PMC7046320  PMID: 31937559


Huntley ML, Gao J, Termsarasab P, et al. "Association between TDP-43 and mitochondria in inclusion body myositis." Lab Invest. 2019;99(7):1041-1048. PMCID: PMC6609472  PMID: 30742062


Wang L, Gao J, Liu J, et al. "Mitofusin 2 Regulates Axonal Transport of Calpastatin to Prevent Neuromuscular Synaptic Elimination in Skeletal Muscles." Cell Metab. 2018;28(3):400-414.e8. PMCID: PMC6125186  PMID: 30017354


Wang W, Arakawa H, Wang L, et al. "Motor-Coordinative and Cognitive Dysfunction Caused by Mutant TDP-43 Could Be Reversed by Inhibiting Its Mitochondrial Localization." Mol Ther. 2017;25(1):127-139. PMCID: PMC5363201  PMID: 28129109


Wang W, Wang L, Lu J, et al. "The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity." Nat Med. 2016;22(8):869-78. PMCID: PMC4974139  PMID: 27348499
Wang W, Wang X, Fujioka H, et al. "Parkinson's disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes." Nat Med. 2016;22(1):54-63. PMCID: PMC4826611  PMID: 26618722