Samuel Yalkowsky, PhD

Professor, Pharmaceutical Sciences

Samuel Yalkowsky, PhD, serves as professor of pharmaceutical sciences, Department of Pharmacology and Toxicology. His current work involves basic research about the relationships between chemical structure and physical phenomena, such as solubility, partitioning, and melting.

Yalkowsky developed the state-of-the-art algorithm for estimation of aqueous solubility and published more than 280 papers and six books about physical proprietary prediction and formulation of poorly soluble drugs. Co-author of two papers that won the Ebert Prize for best scientific paper in the Journal of Pharmaceutical Sciences, he holds six patents and received the University of Arizona Graduate Teaching and Mentoring Award.

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Education & Post Graduate Training: 

PhD, Pharmaceutical Chemistry, University of Michigan, 1969
BS, Pharmacy, Columbia University (New York), 1965

Areas of Research: 

Drug formulation
Melting point
Molecular symmetry
Surface chemistry

Select Publications


Admire B, Lian B, Yalkowsky SH. "Estimating the physicochemical properties of polyhalogenated aromatic and aliphatic compounds using UPPER: part 2. Aqueous solubility, octanol solubility and octanol-water partition coefficient." Chemosphere. 2015;119:1441-1446. PMID: 25454206


Admire B, Yalkowsky SH. "Predicting the octanol solubility of organic compounds." J Pharm Sci. 2013;102(7):2112-9. PMID: 23609069


Yalkowsky SH. "Perspective on improving passive human intestinal absorption." J Pharm Sci. 2012;101(9):3047-50. PMID: 22374839


Jain P, Yalkowsky SH. "Prediction of aqueous solubility from SCRATCH." Int J Pharm. 2010;385(1-2):1-5. PMID: 19819319
Yalkowsky SH, Wu M. "Estimation of the ideal solubility (crystal-liquid fugacity ratio) of organic compounds." J Pharm Sci. 2010;99(3):1100-6. PMID: 19739108