Qing-Yu Zhang, PhD

Professor, Pharmacology & Toxicology

Qing-Yu Zhang, PhD and professor, Department of Pharmacology and Toxicology—studies the function of intestinal P450 enzymes in drug metabolism and safety. Her research investigates the effects of physiological, pathological and environmental factors on drug bioavailability and chemical toxicity, providing strategies to improve therapeutics and prevent intestinal diseases. She is a member of the Southwest Envirnomental Health Sciences Center.

Zhang belongs to the American Society for Biochemistry and Molecular Biology; International Society for the Study of Xenobiotics; American Society for Pharmacology and Experimental Therapeutics, and Society of Toxicology. A reviewer of many academic publications, her awards include the Distinguished Research Award from the University of Michigan, Ann Arbor.

View UA Profile

Education & Post Graduate Training: 

PhD, Biological Chemistry, University of Michigan (Ann Arbor), 1989
MS, Biochemistry, Tulane University (New Orleans, Louisiana), 1984
BS, Biology, Fudan University (China), 1982
 

Areas of Research: 

Biochemistry and molecular biology
Drug metabolism and disposition
Inflammatory bowel disease
Pharmacokinetics
P450 enzymes
Pharmacology and toxicology

Types of Research: 
Laboratory-based Research

Select Publications

2016

Sheng J, Wang Y, Turesky RJ, Kluetzman K, Zhang Q-Y, Ding X. "Novel Transgenic Mouse Model for Studying Human Serum Albumin as a Biomarker of Carcinogenic Exposure." Chem. Res. Toxicol.. 2016;29(5):797-809. PMCID: PMC4868631  PMID: 27028147

2015

Zhu Y, Xie F, Ding L, Fan X, Ding X, Zhang Q-Y. "Intestinal epithelium-specific knockout of the cytochrome P450 reductase gene exacerbates dextran sulfate sodium-induced colitis." J. Pharmacol. Exp. Ther.. 2015;354(1):10-7. PMCID: PMC4468430  PMID: 25926522
Turesky RJ, Konorev D, Fan X, et al. "Effect of Cytochrome P450 Reductase Deficiency on 2-Amino-9H-pyrido[2,3-b]indole Metabolism and DNA Adduct Formation in Liver and Extrahepatic Tissues of Mice." Chem. Res. Toxicol.. 2015;28(12):2400-10. PMCID: PMC4703101  PMID: 26583703

2014

Megaraj V, Ding X, Fang C, Kovalchuk N, Zhu Y, Zhang Q-Y. "Role of hepatic and intestinal p450 enzymes in the metabolic activation of the colon carcinogen azoxymethane in mice." Chem. Res. Toxicol.. 2014;27(4):656-62. PMCID: PMC4002058  PMID: 24552495
Ahlawat S, Xie F, Zhu Y, et al. "Mice deficient in intestinal epithelium cytochrome P450 reductase are prone to acute toxin-induced mucosal damage." Sci Rep. 2014;4:5551. PMCID: PMC4080431  PMID: 24989705
Zhu Y, Ding X, Fang C, Zhang Q-Y. "Regulation of intestinal cytochrome P450 expression by hepatic cytochrome P450: possible involvement of fibroblast growth factor 15 and impact on systemic drug exposure." Mol. Pharmacol.. 2014;85(1):139-47. PMCID: PMC3868902  PMID: 24184963

2013

Zhang P, Jia K, Fang C, Zhou X, Ding X, Zhang Q-Y. "Dietary regulation of mouse intestinal P450 expression and drug metabolism." Drug Metab. Dispos.. 2013;41(2):529-35. PMCID: PMC3558856  PMID: 23160819