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Jianqin Lu, BPharm, PhD

Assistant Professor, Pharmaceutics and Pharmacokinetics
Director, Pharmaceutics and Pharmacokinetics Track
Assistant Professor, BIO5 Institute
Member, NCI designated UA Comprehensive Cancer Center
Member, Southwest Environmental Health Sciences Center

Jianqin Lu, BPharm, PhD, is an Assistant Professor of Pharmaceutical Sciences in Pharmaceutics and Pharmacokinetics at R. Ken Coit College of Pharmacy (RKCCOP). The Lu research laboratory strives to develop innovative, safe, and efficacious therapeutics at the interface of drug delivery, synthetic chemistry, pharmaceutics, nanotechnology, biomaterials, and tumor immunology to address the pressing unmet needs in current cancer and other diseases therapy and prevention, particularly in the emerging field of combination immunochemotherapy.

Dr. Lu’s research work has been published in Nature Nanotechnology, Nature Communications, Biomaterials, etc, and has resulted in a Maximizing Investigators' Research Award (MIRA) (R35) from NIH/NIGMS, a Pharmaceutical Research and Manufacturers of America (PhRMA) Foundation Research Starter Grant in Drug Delivery, and several pilot and seed grants from the State of Arizona's Technology and Research Initiative Fund (TRIF)/BIO5 Institute and NIH-sponsored The Southwest Environmental Health Sciences Center (SWEHSC).

Recipient of the Norman R. and Priscilla A. Farnsworth Award at the University of Pittsburgh, the NIH/NCI Ruth L. Kirschstein Institutional National Research Service Award (T32) in Tumor Immunology, and the 2022 American Association of Colleges of Pharmacy (AACP) Pharmaceutics Research Award, Dr. Lu serves as the Director for Pharmaceutics and Pharmacokinetics Track at RKCCOP, the Secretary of Knowledge Management in AACP Pharmaceutics Section, and the Associate Editor for Frontiers in Medical Technology: Nano-Based Drug Delivery.

 

Education & Post Graduate Training: 

Postdoc, Nanomedicine/Tumor Immunology, University of California, Los Angeles, 2019
Postdoc, Nanomedicine, The University of Chicago, Chicago, 2015
PhD, Pharmaceutics, University of Pittsburgh, Pittsburgh, 2014
BS, Pharmacy, Hunan University of Chinese Medicine, Changsha, China, 2010

Areas of Research: 

Drug Delivery
Nanomedicine
Pharmaceutics and Pharmacokinetics
Nano-ImmunoEngineering
Cancer Immunotherapy
Chemotherapy
Biomaterials

Types of Research:

Laboratory-based Research
Basic and Applied Sciences
Industry
Translational Medicine

Select Publications

2022

Wang Z, Li W, Park J, Gonzalez KMarie, Scott AJames, Lu J. "Camptothesome elicits immunogenic cell death to boost colorectal cancer immune checkpoint blockade." J Control Release. 2022. PMID: 35926754
Li W, Gonzalez KMarie, Chung J, Kim M, Lu J. "Surface-modified nanotherapeutics targeting atherosclerosis." Biomater Sci. 2022. PMID: 35980230
Wang Z, Cordova LEstrella, Chalasani P, Lu J. "Camptothesome Potentiates PD-L1 Immune Checkpoint Blockade for Improved Metastatic Triple-Negative Breast Cancer Immunochemotherapy." Mol Pharm. 2022;19(12):4665-4674. PMID: 36413426

2021

Li W, Little N, Park J, Foster CAlexander, Chen J, Lu J. "Tumor-Associated Fibroblast-Targeting Nanoparticles for Enhancing Solid Tumor Therapy: Progress and Challenges." Mol Pharm. 2021;18(8):2889-2905. PMID: 34260250
Wang Z, Little N, Chen J, et al. "Immunogenic camptothesome nanovesicles comprising sphingomyelin-derived camptothecin bilayers for safe and synergistic cancer immunochemotherapy." Nat Nanotechnol. 2021. PMID: 34385682

2020

Wang Z, Chen J, Little N, Lu J. "Self-assembling Prodrug Nanotherapeutics for Synergistic Tumor Targeted Drug Delivery." Acta Biomater. 2020. PMCID: PMC7245299  PMID: 32454086

2019

Wang X, Chang CHyun, Jiang J, et al. "The Crystallinity and Aspect Ratio of Cellulose Nanomaterials Determine Their Pro-Inflammatory and Immune Adjuvant Effects In Vitro and In Vivo." Small. 2019;15(42):e1901642. PMCID: PMC6800804  PMID: 31461215
Liu Q, Wang X, Liu X, et al. "Use of Polymeric Nanoparticle Platform Targeting the Liver To Induce Treg-Mediated Antigen-Specific Immune Tolerance in a Pulmonary Allergen Sensitization Model." ACS Nano. 2019;13(4):4778-4794. PMCID: PMC6506187  PMID: 30964276
Liu X, Jiang J, Chan R, et al. "Improved Efficacy and Reduced Toxicity Using a Custom-Designed Irinotecan-Delivering Silicasome for Orthotopic Colon Cancer." ACS Nano. 2019;13(1):38-53. PMCID: PMC6554030  PMID: 30525443
Ji Y, Liu X, Huang M, et al. "Development of self-assembled multi-arm polyrotaxanes nanocarriers for systemic plasmid delivery in vivo." Biomaterials. 2019;192:416-428. PMCID: PMC6934403  PMID: 30500723
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