Ganga Reddy Velma

Postdoctoral Research Associate

Dr. Velma joined the University of Arizona in January 2021 as a Postdoctoral Research Associate where he actively involved in the AD and Type 2 diabetes (T2D) drug discovery projects. For the last 8 years, he involved in various lead discovery projects in the field of medicinal chemistry and also developed efficient methodologies for the construction of organic frameworks, C-C, C-N, and C-O bond formation reactions which allow new synthetic routes for the preparation of bioactive heterocyclic molecules. Skilled in lead designing, executing multi-step organic synthesis, small heterocyclic molecules (gram scale to mg scale), and purification of high-quality target molecules for various therapeutic applications.

Patents

Education & Post Graduate Training: 

Postdoctoral Fellow, RMIT-University, Melbourne, Australia, 2020
PhD, CSIR-Indian Institute of Chemical Technology, Hyderabad, India 2019
Msc, Osmania University, Hyderabad, India, 2011
BSc, Osmania University, Hyderabad, India, 2009

 

Select Publications

2021

Sana S, Reddy VGanga, T Reddy S, et al. "Cinnamide derived pyrimidine-benzimidazole hybrids as tubulin inhibitors: Synthesis, in silico and cell growth inhibition studies." Bioorg Chem. 2021;110:104765. PMID: 33677248

2020

Jadala C, Reddy VGanga, Krishna NHari, Shankaraiah N, Kamal A. "Base-mediated 1,3-dipolar cycloaddition of pyridinium bromides with bromoallyl sulfones: a facile access to indolizine scaffolds." Org Biomol Chem. 2020;18(42):8694-8701. PMID: 33084715
Ragi NChary, Velma GReddy, Pallerla PKumar, et al. "Identification and characterization of forced degradation products of vortioxetine by LC/MS/MS and NMR." J Pharm Biomed Anal. 2020;188:113442. PMID: 32622114
Sana S, Reddy VGanga, Bhandari S, et al. "Exploration of carbamide derived pyrimidine-thioindole conjugates as potential VEGFR-2 inhibitors with anti-angiogenesis effect." Eur J Med Chem. 2020;200:112457. PMID: 32422489

2019

Reddy VGanga, T Reddy S, Jadala C, et al. "Pyrazolo-benzothiazole hybrids: Synthesis, anticancer properties and evaluation of antiangiogenic activity using in vitro VEGFR-2 kinase and in vivo transgenic zebrafish model." Eur J Med Chem. 2019;182:111609. PMID: 31445229
Velma GReddy, Jampaiah D, Chalkidis A, Sabri YM, Mayes ELH, Bhargava SK. "Highly dispersed cobalt oxide nanoparticles on manganese oxide nanotubes for aerobic oxidation of benzyl alcohol." Catalysis Communications. 2019;130.
V Reddy G, T Reddy S, Privér SH, et al. "Synthesis of Gold(I) Complexes Containing Cinnamide: In Vitro Evaluation of Anticancer Activity in 2D and 3D Spheroidal Models of Melanoma and In Vivo Angiogenesis." Inorg Chem. 2019;58(9):5988-5999. PMID: 30985125

2018

V Reddy G, Bonam SReddy, T Reddy S, et al. "4β-amidotriazole linked podophyllotoxin congeners: DNA topoisomerase-IIα inhibition and potential anticancer agents for prostate cancer." Eur J Med Chem. 2018;144:595-611. PMID: 29289884

2016

T Reddy S, V Reddy G, Kulhari H, Shukla R, Kamal A, Bansal V. "Synthesis of (Z)-1-(1,3-diphenyl-1H-pyrazol-4-yl)-3-(phenylamino)prop-2-en-1-one derivatives as potential anticancer and apoptosis inducing agents." Eur J Med Chem. 2016;117:157-66. PMID: 27092413
V Reddy G, T Reddy S, V Nayak L, et al. "Design, synthesis and biological evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)-1,3-diphenyl-1H-pyrazole-4-carboxamides as CDK1/Cdc2 inhibitors." Eur J Med Chem. 2016;122:164-177. PMID: 27344493