Chandra Shekhar Madasu

Assistant Scientific Investigator
Research Scientist
Postdoctoral Research Associate

Dr. Chandra Shekhar Madasu joined as a Postdoctoral Research Associate in the Department of Pharmacology and Toxicology, The University of Arizona. He is engaged in the PROTAC based drug discovery projects.  Dr. Chandra innovative researcher in the field of Synthetic/Natural Product Medicinal Chemistry. Multidisciplinary scientist with extensive experience in organic synthesis and development of new drugs for the treatment of diverse type of diseases. Experienced in rational drug design, cascade and multicomponent reactions for the library synthesis, and understanding SAR profiles that allow for potential identification of lead compounds in early-stage lead discovery.

Education & Post Graduate Training: 

Postdoctoral Research Associate, College of Pharmacy,  The University of Arizona, 2020-Present
Ph.D, Indian Institute of Chemical Technology, Hyderabad, India, 2017
M.S, Andhra University, Visakhapatnam, India, 2009
B.Sc, Kakatiya University, Warangal, India, 2007

Areas of Research: 
  • Small molecule synthesis
  • NMR Characterization
Types of Research: 
Database Research
Laboratory-based Research
Literature Reviews

Select Publications


Xu Y-ming, Madasu C, Liu MX, et al. "Cycloartane- and Lanostane-Type Triterpenoids from the Resin of Parthenium argentatum AZ-2, a Byproduct of Guayule Rubber Production." ACS Omega. 2021;6(23):15486-15798.


Madasu C, Karri S, Sangaraju R, Sistla R, Uppuluri MVenkata. "Synthesis and biological evaluation of some novel 1,2,3-triazole hybrids of myrrhanone B isolated from Commiphora mukul gum resin: Identification of potent antiproliferative leads active against prostate cancer cells (PC-3)." European Journal of Medicinal Chemistry. 2020;188.


Mallavadhani U.V., Madasu C., S. R. "Design, synthesis, anti-inflammatory, cytotoxic and cell based studies of some novel side chain analogues of myrrhanones A & B isolated from the gum resin of Commiphora mukul." Bioorganic Chemistry. 2019;82:306-323.


Madasu C., Gudem S., Sistla R., Uppuluri V.M. "Synthesis and anti-inflammatory activity of some novel pyrimidine hybrids of myrrhanone A, a bicyclic triterpene of Commiphora mukul gum resin." Monatshefte fur Chemle. 2017;148(12):2183-2193.


Madasu C., Nayak V.L., Ramakrishna S., Mallavadhani U.V. "Novel triazole hybrids of myrrhanone C, a natural polypodane triterpene: Synthesis, cytotoxic activity and cell based studies." European Journal of Medicinal Chemistry. 2016;114:293-307.


Mallavadhani U.V., Madasu C., Nayak V.L., Ramakrishna S. "Synthesis and anticancer activity of novel fused pyrimidine hybrids of myrrhanone C, a bicyclic triterpene of Commiphora mukul gum resin." Molecular Diversity. 2015;19(4):745-757.