Bonnie LaFleur, PhD

Research Professor
Director of Health Outcomes & PharmacoEconomic Research (HOPE) Center

Bonnie received her PhD in Biometrics (statistical study of biological phenomena) from The University of Colorado Health Sciences Center (now part of the University of Colorado, Denver) in 1999 and was a postdoctoral fellow with the CDC at the National Center for Health Statistics, where she worked on methods of analysis for the aging and chronic diseases. Her scientific expertise is in immunobiology, oncology, and aging. Most of her methodologic work is in statistical methods for precision healthcare, specifically biomarkers.

Bonnie was a tenure-track faculty in Biostatistics for 15 years, including appointments in the Department of Biostatistics at George Washington University, Vanderbilt University, and The University of Utah before joining the Mel and Enid Zuckerman College of Public Health in 2008 as an Associate Professor. While at George Washington University she was the Director of Biostatistics in the Center for Health Services Research (an early focus of quantitative science that was the predicate for Health Outcomes Research).

In 2012 she joined Roche Diagnostics and was Director of Data Management and Biostatistics and a few years later was Vice President of Data Science and Companion Diagnostics Program Lead at HTG Molecular Diagnostics. During her time in industry, she developed several molecular biomarkers that led to patents and some were submitted and approved for use by the FDA. She also managed customer relations for Key Opinion Leaders and the pharmaceutical industry. She joined the UArizona community again in 2018 as a Research Professor in The BIO5 Institute and is currently the Core Director and Project Lead on several program project grants at the University of Arizona.

Education & Post Graduate Training: 

PhD, University of Colorado Denver, 1999
MPH, San Diego State Universiyt, 1995
BA, University of California, San Diego, 1990

Select Publications


Shroff RT, Chalasani P, Wei R, et al. "Immune Responses to COVID-19 mRNA Vaccines in Patients with Solid Tumors on Active, Immunosuppressive Cancer Therapy." medRxiv. 2021. PMCID: PMC8132263  PMID: 34013289
Akinbami LJ, Petersen LR, Sami S, et al. "Coronavirus Disease 2019 Symptoms and Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Positivity in a Large Survey of First Responders and Healthcare Personnel, May-July 2020." Clin Infect Dis. 2021;73(3):e822-e825. PMCID: PMC7929062  PMID: 33515250


Thorne CA, Hanson AJ, Schneider J, et al. "Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α." Nat Chem Biol. 2010;6(11):829-36. PMCID: PMC3681608  PMID: 20890287


MacDonald TJ, Brown KM, LaFleur B, et al. "Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease." Nat Genet. 2001;29(2):143-52. PMID: 11544480