Yong Qin, PhD

My research in the Medicinal and Natural Products Chemistry Program (University of Arizona) focused on targeting promoter regions of Platelet-derived growth factor (PDGF) ligand and receptor in tumors. Aberrant expression of PDGF-A and PDGF receptor-β (PDGFR-β) play critical roles in the angiogenesis and proliferation of several malignancies. I explored the transcriptional regulatory role of the G-quadruplex-forming regions in the promoters of human PDGF-A and PDGFR-β, and identified new targets for developing small molecules to modulate their expression in tumors. On the basis of my studies, we proposed that ligand-mediated stabilization of the G-quadruplex structure in the proximal promoter region of human PDGF-A or PDGFR-β can be used to modulate the expression of these proto-oncogenes. I am currently a postdoctoral fellow in the Experimental Therapeutics Department at M.D. Anderson Cancer Center doing research in targeting iNOS to treat melanoma and other cancer. My research is focusing on understanding the transcriptional mechanism that controls iNOS expression in melanoma. I am also exploiting the transcription and genetics profiles of melanoma. The ultimate goal of my studies is to identify unique biomarker and druggable target for melanoma. Subsequently, we are trying to design and develop a high throughput screen method to identify the small molecule, which can modulate the iNOS pathway in melanoma.
Pharmaceutical Sciences
Drug Discovery and Development
Dissertation Title: 
“Targeting the Promoter Regions of the PDGF Ligand and Receptor”
1. Characterization of the G-quadruplexes in the duplex nuclease hypersensitive element of the PDGF-A promoter and modulation of PDGF-A promoter activity by TMPyP4. Qin Y, Rezler EM, Gokhale V, Sun D, Hurley LH. Nucleic Acids Res. 2007;35(22):7698-713.
2. Structures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regions. Qin Y, Hurley LH. Biochimie. 2008 Feb 29.
Alumna or Alumnus: 
Alumni Title/Position/Employer: 
Post Doctoral Fellow M.D. Anderson Cancer Center Houston, TX