Yan He, PhD

Pharmaceutical Sciences
Pharmaceutics and Pharmacokinetics
Dissertation Title: 
“Solubilization of Poorly Water-Soluble Drugs: Theory and Applications”

Year Graduated: 2005
Pharmaceutical Sciences Department, Sanofi-Aventis

Academic & Professional Updates
My dissertation focused on the theory and application of most commonly used solubilization techniques: pH adjustment, micellization, complexation and pH adjustment combined with one of the other techniques. The high efficiency of the combinations of pH adjustment with either cosolvency, micellization or complexation is evaluated, emphasized and illustrated by the studied eight ionizable compounds. This dissertation provides guidance for the selection of a solubilization technique for a compound based on the physicochemical properties and the dose requirement.

1. He, Y., Yalkowsky, S.H., 2005. Solubilization on poorly water soluble drugs: minireview.
2. He, Y., Tabibi, S.E., Yalkowsky, S.H., 2005. Solubilization on two structurally related anticancer drugs: XK-469 and PPA.
3. Johnson, J.L.H., He, Y., Chow, H.-H. S., Dorr, R., Brenner, T.L., Yalkowsky, S.H., 2004. An oral formulation of PG301029 in HPβCD (hydroxypropyl-β-cyclodextrin).
4. He, Y., Johnson, J.L.H., Yalkowsky, S.H., 2005. Oral formulation of a novel antiviral agent, PG301029, in a mixture of Gelucire® 44/14 and DMA (2:1, w/w). AAPS PharmSciTech. 6(1) Article 1.
5. He, Y., Yalkowsky, S.H., 2004. Solubilization of the neutral and charged forms of 2,4,6-trichlorophenol by hydroxypropyl-b-cyclodextrin, or methyl-b-cyclodextrin in water. J. Hazard.  Mater.  108(1-2), 129-131.
6. Johnson, J.L.J., He, Y., Yalkowsky, S.H., 2003. Validation of an in vitro model for prediction of in vivo phlebitis. J. Pharm. Sci. 92, 1574-1581. 
7. He, Y., Li, P., Yalkowsky, S.H., 2003. Solubilization of fluasterone in cosolvent/cyclodextrin combinations. Int. J. Pharm. 264(1-2), 25-34.
8. Ran, Y., He, Y., Yang, G., Johnson, J.H.L., Yalkowsky, S.H., 2002. Estimation of aqueous solubility of organic compounds by using the general solubility equation (GSE). Chemosphere.  48(5), 487-509.
Originally posted: August 21, 2014
Last updated: October 8, 2015
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