My research in the Medicinal and Natural Products Chemistry Program focused on the validation and drug targeting of the Aurora kinases to treat cancer. I used genetic and pharmacological approaches to perturb the Aurora kinase signaling pathway in order to understand the biological consequences and potential clinical outcomes of an Aurora-targeted therapy. Additionally, I employed a structure-based approach to design and develop a novel class of small molecule Aurora kinase inhibitors. I am currently a manager in Discovery Biology at SuperGen, Inc.
Drug Discovery and Development
"Targeting the Aurora Kinases to Treat Pancreatic Cancer"
1. S.L. Warner, H. Han, D.J. Bearss and D.D. Von Hoff. Targeting Aurora-2 kinase in cancer. Molecular Cancer Therapeutics 2: 589–595 (2003).
Alumna or Alumnus:
Manager, Discovery Biology, SuperGen, Inc., Salt Lake City, UT