Shuxi Qiao, PhD

My graduate research aimed at targeting cellular stress pathways (oxidative, metabolic and proteotoxic stress) using small drug molecules for chemotherapeutic intervention in skin cancer. With a focus on drug discovery and target validation of small molecule stress modulators, I have provided mechanistic insight into the molecular targets of three experimental chemotherapeutics including thiostrepton, D-penicillamine and amodiaquine.
Status: 
Alumni
Degree: 
PhD
Program: 
Pharmacology and Toxicology
Track: 
Pharmacology and Toxicology
Dissertation Title: 
“Pharmacological Modulation of Oxidative and Protestoxic Stress for Antimelanoma Intervention”
Honors and Achievements: 
1. Mary E. Caldwell Memorial Scholarship, 2011-12.
Publications: 
1. The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death. Qiao S, Tao S, Rojo de la Vega M, Park SL, Vonderfecht AA, Jacobs SL, Zhang DD, Wondrak GT. Autophagy. 2013 Dec;9(12):2087-102. doi: 10.4161/auto.26506. Epub 2013 Oct 8.
2. Phenotypic identification of the redox dye methylene blue as an antagonist of heat shock response gene expression in metastatic melanoma cells. Davis AL, Cabello CM, Qiao S, Azimian S, Wondrak GT. Int J Mol Sci. 2013 Feb 19;14(2):4185-202.
3. D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Qiao S, Cabello CM, Lamore SD, Lesson JL, Wondrak GT. Apoptosis. 2012 Oct;17(10):1079-94. doi: 10.1007/s10495-012-0746-x.
4. Thiostrepton is an inducer of oxidative and proteotoxic stress that impairs viability of human melanoma cells but not primary melanocytes. Qiao S, Lamore SD, Cabello CM, Lesson JL, Muñoz-Rodriguez JL, Wondrak GT.Biochem Pharmacol. 2012 May 1;83(9):1229-40.
5. The redox antimalarial dihydroartemisinin targets human metastatic melanoma cells but not primary melanocytes with induction of NOXA-dependent apoptosis. Cabello CM, Lamore SD, Bair WB 3rd, Qiao S, Azimian S, Lesson JL, Wondrak GT. Invest New Drugs. 2012 Aug;30(4):1289-301.
6. Proteomic identification of cathepsin B and nucleophosmin as novel UVA-targets in human skin fibroblasts. Lamore SD, Qiao S, Horn D, Wondrak GT. Photochem Photobiol. 2010 Nov-Dec;86(6):1307-17.
Alumna or Alumnus: 
Alumna
Alumni Title/Position/Employer: 
Postdoctoral Research Fellow, Massachusetts General Hospital, Harvard Medical
Career Type: 
Academia