Shawn Wnek, PhD

Pharmacology and Toxicology
Pharmacology and Toxicology
Dissertation Title: 
“Mechanisms of Malignant Transofrmation of Human Urothelial Cells by Monomethylarsonous Acid”

Year Graduated: 2011
Career Type: Industry
Toxicologist, Center for Toxicology and Environmental Health, LLC Little Rock, AK

Academic & Professional Updates
I am currently a toxicologist at CTEH doing environmental consulting focused on emergency response toxicology and human health consulting to the public and private sectors.  CTEH specializes in scientific expertise of toxicology, risk assessment, industrial hygiene, occupational health and response to emergencies involving releas of chemicals in the environment.

1. Wnek, S.M., Kuhlman,, C.L., Camarillo, J. M., Medeiros, M.K., Liu, K.J., Lau, S.S. and Gandolfi, A.J. Interdependent genotoxic mechanisms of monomethylarsonous acid: Role of ROS-induced DNA damage and poly(ADP-ribose) polymerase-1 inhibition in the malignant transformation of urothelial cells. Toxicol. Appl. Pharm. 257: 1-13, 2011.
2. Wnek SM, Jensen TJ, Severson PL, Futscher BW, Gandolfi AJ. Monomethylarsonous acid produces irreversible events resulting in malignant transformation of a human bladder cell line following 12 weeks of low-level exposure. Tox Sci, 116(1):44-57, 2010.
3. Medeiros M, Zheng X, Novak P, Wnek SM, Chyan V, Gandolfi AJ. Global gene expression changes in human urothelial cells exposed to low-level monomethylarsonous acid. Toxicology, 291(1-3):102-112, 2012.
Originally posted: August 22, 2014
Last updated: October 8, 2015
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