Robert Brown, PhD

Pharmaceutical Sciences
Drug Discovery and Development
Dissertation Title: 
"The regulatory significance and molecular targeting of novel non-B-DNA secondary structures formed from the PDGFR-β core promoter nuclease hypersitivity element"

Year Graduated: 2014
Career Type: Academia
NIEHS Postdoctoral Fellow, Holly Springs, North Carolina

BS, Molecular and Cellular Biology (2007) University of Arizona, Tucson, AZ BS, Biochemistry and Molecular Biophysics (2007) University of Arizona, Tucson, AZ

Honors & Achievements
1. Research Supplement to Promote Diversity in Health-Related Research, 2010-12.
2. Graduate Track Awards: Outstanding Research, 2012-13.

1. Frett B, Brown RV, Ma M, Hu W, Han H, and Li HY. Therapeutic Melting Pot of Never in Mitosis Gene A Related Kinase 2 (Nek2): A Perspective on Nek2 as an Oncology Target and Recent Advancements in Nek2 Small Molecule Inhibition. J Med Chem. 2014 Feb 25. [Epub ahead of print].
2. Brown RV, Gaerig VC, Simmons T, and Brooks TA. Helping Eve overcome ADAM: G-quadruplexes in the ADAM-15 promoter as new molecular targets for breast cancer therapeutics. Molecules. 2013 Dec 5;18(12):15019-34.
3. Chen Y, Agrawal P, Brown RV, Hatzakis E, Hurley L, and Yang D. The major G-quadruplex formed in the human platelet-derived growth factor receptor β promoter adopts a novel broken-strand structure in K+ solution. J Am Chem Soc. 2012 Aug 15; 134(32):13220-3.
4. Brown RV, Danford FL, Gokhale V, Hurley LH, and Brooks TA. Demonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex. J Biol Chem. 2011 Nov 25;286(47):41018-27.
5. Brown RV and Hurley LH. DNA acting like RNA. Biochem Soc Trans. 2011 Apr;39(2):635-40.
Originally posted: August 28, 2014
Last updated: December 19, 2016
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