Mark Jimenez-Canet, PhD

My long-term research interests are to better understand the complex association between liver, muscle and adipose tissue energy homeostasis in the setting of obesity and metabolic diseases. Specifically, my current goal is to functionally link the development of metabolic inflammation to peripheral insulin resistance. As a postdoctoral fellow at the University of Michigan, I intend to expand my technical expertise to complement my current level of training so that I may make a successful transition into a career as an independent scientist.
Status: 
Alumni
Degree: 
PhD
Program: 
Pharmacology and Toxicology
Track: 
Pharmacology and Toxicology
Dissertation Title: 
"Coordinated Regulation of Hepatic and Renal Membrane Transporters in Experimental Nonalcoholic Steatohepatitis"
Year Enrolled: 
2009
Education: 
B.S, Molecular and Cellular Biology (2007) University of Arizona, Tucson, AZ Minors in Chemistry and Mathematics
Honors and Achievements: 
1. Vice President- Postdoctoral Society, Department of Molecular and Integrative Physiology, 2015.
2. Mechanisms Specialy Section Renal Toxicology Mechanisms Student Poster Award-3rd Place, 2013-14.
3. NIEHS Training Grant - Environmental Toxicology of Human Diseases, 2012, 2013 (32, 33).
4. Graduate Track Awards: Academic Excellence, 2013-14.
5. Mountain West Society of Toxicology Senior Graduate Student Representative, 2012.
6. Pharmacology and Toxicology Graduate Student Representative, 2010.
7.  Science Foundation of Arizona Student Fellowship, 2009.
Publications: 
1. Hardwick, R.N., Fisher, C.D., Street, S.N., Canet, M.J., Cherrington, N.J. (2011) Molecular Mechanism of Altered Ezetimibe Disposition in Nonalcoholic Steatohepatitis. Drug Metabolism and Disposition. 40(3), 405-460.
2. Hardwick, R.N., Fisher, C.D., Canet, M.J., Scheffer, G.L., Cherrington, N.J. (2011) Variations in ABC-Transporter Regulation During the Progression on Human Nonalcoholic Fatty Liver Disease. Drug Metabolism and Disposition. 39(12), 2395-2402.
3. Hardwick, R.N, Fisher, C.D, Canet, M.J, Lake, A.D, Cherrington, N.J. (2010) Diversity in Antioxidant Response Enzymes in Progressive Stages of Human Nonalcoholic Fatty Liver Disease. Drug Metabolism and Disposition. 38(12), 2293-2301.
4. Mark J Canet, Rhiannon N. Hardwick, April D Lake, Anika L, Dzierlenga, John D. Clarke, Nathan J. Cherrington (2014) Modeling Human Nonalcoholic Steatohepatitis-Associated Changes in Drug Transporter Exdpression Using Experimental Rodent Models; Drug Metabolism and Disposition. 42(4); 586-95.
5. Nathan J. Cherrington, Teresa E. Estrada, Harrison A. Frisk, Mark J. Canet, Rhiannon N. Hardwick, Bohuslav Dvorak, Katie Lux, Melissa D. Halpern (2013) The Hepatic bile Acid Transporters Ntcp and Mrp2 and downregulated in Experimental Necrotizing Enterocolitis; American Journal or Physiology Gastrointestinal and Liver Physiology. 304(1); G48-56.
6. Mark J. Canet, Rhiannon N. Hardwick, April D. Lake, Michael J. Koplin, Walter T. Klimecki, George L. Scheffer, A. Jay Gandolfi, Nathan J. Cherrington (2012) Altered Arsenic Disposition in Experimental Nonalcoholic Fatty Liver Disease. Drug Metabolism and Disposition. 40(9); 1817-24.
Alumna or Alumnus: 
Alumnus
Alumni Title/Position/Employer: 
Postdoctoral Fellow, Dept. of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI
Career Type: 
Academia