Huadong Tang, PhD

Pharmaceutical Sciences
Pharmaceutics and Pharmacokinetics
Dissertation Title: 
“Allometric Scaling for Predicting Human Drug Clearance”

Year Graduated: 2005
Senior Research Scientist, Wyeth Research, Pearl River, NY

Academic & Professional Updates
My research as a student in pharmaceutics focused on examination and evaluation of allometry technique in predicting human PK parameters; Development of new models for predicting human PK parameters; Examination of species/body weight dependency of allometry technique for predicting human PK parameters; Mathematical examination of the functionality of correction factors used in allometry; Pharmacokinetic modeling of drug disposition in hair; Development of a pharmacokinetic-based model for predicting the efficiency of hemodialysis; Determination of the distribution pattern of P-glycoprotein in the gastric intestinal tract of micropigs. I am currently at Wyeth Research doing pharmacokinetics within drug safety and metabolism. I Assist Bioanalytical R&D and Drug Safety staff in the interpretation of PK and TK data, perform simulations to aid study design and assist in the design. I conduct analysis of specialized PK or PK/PD experiments. I also predict human pharmacokinetic parameters and determine the First Dose in Humans to aid clinical study design, and also design and analyze GLP/non-GLP PK and TK experiments Preparation and review of technical reports, regulatory submissions and manuscripts for publication.

1. Tang H, Pak Y, Mayersohn M. Protein expression pattern of P-glycoprotein along the gastrointestinal tract of the Yucatan micropig. J Biochem Mol Toxicol, 2004, 18 (1); 8-12.
2. Tang H, Mayersohn M. A global examination of allometric scaling in predicting human clearance and the prediction of large vertical allometry. J Pharm Sci, 2005, in press.
3. Tang H, Mayersohn M. A novel model for prediction of humanclearance by allometric scaling. Drug Metabolism and Disposition, 2005, in press.
4. Tang H, Mayersohn M. Accuracy of allometrically-predicted pharmacokinetic parameters in humans – role of species selection. Drug Metabolism and Disposition, 2005, in press.
5. Tang H, Mayersohn M. A Mathematical Description of the Functionality of Correction Factors Used in Allometry for Predicting Human Drug Clearance. Drug Metabolism and Disposition, 2005, in press.
6. Tang H, Zhang D, and Mayersohn M. Evaluation of a swine model for assessment of absolute oral drug bioavailability in humans: evaluation of the literature. To be submitted to Life Sci.
7. Tang H, Mayersohn M. Predicting the efficiency of hemodialysis with unbound volume of distribution. Submitted to Br J Clin Pharmacol.
Originally posted: August 21, 2014
Last updated: October 8, 2015
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