Guillermo Martinez-Ariza, PhD

Pharmaceutical Sciences
Drug Discovery and Development
Dissertation Title: 
Exploiting Molecular Diversity to Access Biologically Relevant Chemotypes

Year Graduated: 2016
Development Chemist at HP, Inc.

Pharmaceutical Chemistry, Licenciatura (2011)

Honors & Achievements
1. CONACyT(Mexican National Council for Science and Technology) doctoral scholarship, 2012-Present.
2. Mary E. Caldwell Memorial Scholarship, 2014-15.
3. Graduate Track Travel Award, 2014-15.
4. GPSC Research Grant, 2014-15.
5. GPSC Travel Award, 2014-15.
6. Graduate Track Awards: Outstanding Research, 2015-16.
7. AzHIMSS Fellowship Award 2016

1. Martinez-Ariza, G. et al. One-Pot Two-Step Multicomponent Process of Indole and Other Nitrogenous Heterocycles or Amines toward α‑Oxo-acetamidines. Org. Lett. 2016, 18, 1864.
2. Martinez-Ariza, G. et al. The Synthesis of Stable, Complex Organocesium Tetramic Acids via the Ugi reaction and Cesium Carbonate promoted Cascades. Angew. Chem. Int. Ed. 2015, 54, 11671.
3. Martinez-Ariza, G.; Hulme, C. Recent advances in allosteric androgen receptor inhibitors for the potential treatment of castration-resistant prostate cancer. Pharma. Patent Anal. 2015, 4, 387.
4. Xu, Z.; Martinez-Ariza, G.; et al., C. Z-stereoselective synthesis of benzimidazolones via domino processes derived from an elegant benzodiazepine ring contraction. J. Org. Chem. 2015, 80, 9007.
5. Rabanal-Leon, W.A.; Martinez-Ariza, G.; et al. Computational Study of Organo-Cesium Complexes and the Possibility of Lanthanide/Actinide ions Substitution. Chem. Phys. Lett. 2015, 641, 181.
6. Medda, F.; Martinez-Ariza, G. et al. A facile route for the synthesis of novel imidazo-tetrazolodiazepinones via post-condensation modifications of the Ugi-azide adduct. Tetrahedron Lett. 2015, 56, 5295. *Highlighted in Synfacts.
7. Tsai, L.C.L.; Xie, L.; Dore, K.; Xie, L.; Martinez-Ariza, G. et al. Zeta inhibitory peptide disrupts electrostatic interaction that maintain atypical protein kinase C in its active conformation on the scaffold p62. J. Biol. Chem. 2015, 290, 21845.
8. Martinez-Ariza, G.; Nunez-Rios, J.; Lee, Y. S.; Hulme, C. Acetyl cyanide as a cyanide source in a tandem catalyst free [4+1] cycloaddition-Strecker cascade. Tetrahedron Lett. 2015, 56, 1038. *Highlighted in Synfacts.
9. Roberts, S. A.; Martinez-Ariza, G. et al. Hulme, C. Crystal Structures of N-tert-butyl-3-(4-Fluorophenyl)-5-oxo-4-[2-(Trifluoromethoxy) phenyl]-2, 5-Dihydrofuran-2-Carboxamide and 4-(2H-1, 3-Benzodioxol-5-yl)-N-Cyclohexyl-5-oxo-3-[4-(Trifluoromethyl) phenyl]-2, 5-Dihydrofuran-2-Carboxamide. Acta Cryst. 2015, E71, 199.  
10. Martinez-Ariza, G. et al. Benzimidazol-2-one scaffolds derived from unique domino processes centered upon elegant benzodiazepine ring rearrangements. Abstracts of Papers, 249th ACS National Meeting, Denver, CO, USA, March 22-26, 2015, ORGN-509.
11. Hulme, C.; Ayaz, M.; Martinez-Ariza, G. et al. Recent Advances in Multicomponent Reaction Chemistry, in Small Molecule Medicinal Chemistry: Strategies and Technologies (eds W. Czechtizky and P. Hamley), John Wiley & Sons, Inc, Hoboken, NJ. 2015, Chapter 6, 145.
12. Martinez-Ariza, G. et al. Synthesis of diverse nitrogen-enriched heterocyclic scaffolds using a suite of tunable one-pot multicomponent reactions. J. Org. Chem. 2014, 79, 5153. *Highlighted by the editor.
13. Ayaz, M.; Martinez-Ariza, G. et al. A robust protocol for the synthesis of quinoxalines and 5H-benzo[e][1,4]diazepines via the acid-less Ugi reaction. Synlett. 2014, 25, 1680.
14. Martinez-Ariza, G. et al. Diversity-enabling multicomponent reactions of 2-hydrazino-azines for the synthesis of nitrogen-enriched bicyclic heterocycles. Abstracts of Papers, 248th ACS National Meeting, San Francisco, CA, United States, August 10-14, 2014, ORGN-968.
15. Martinez-Ariza, G. et al. A simple one-pot 2-step N-1-alkylation of indoles with α-iminoketones toward the expeditious 3-step synthesis of N-1-quinoxaline-indoles. Tetrahedron Lett. 2013, 54, 6719.
16. Martinez-Ariza, G.; Dietrich, J. et al. A tandem [3+2] cycloaddition-elimination cascade reaction to generate pyrrolo-[3,4-c] pyrrole-1,3-diones. Synlett 2013, 24, 1801. *Highlighted in Synfacts.
17. Roberts, S. A., Martinez-Ariza, G. et al. Acta Cryst. 2012, E68, 496


Originally posted: October 24, 2014
Last updated: March 22, 2017
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