Davide Botta, PhD

Pharmaceutical Sciences
Drug Discovery and Development
Dissertation Title: 
“The Determination of the 3-Dimensional Structure of Poly/(ADP-ribose/) Glycohydrolase by X-ray Crystallography”

Year Graduated: 2010
Career Type: Academia
Post-doctoral fellow, University of Rochester, Scottsville, NY

Academic & Professional Updates
Advisor: Myron K. Jacobson
I am currently conducting a post-doctoral fellowship at the University of Rochester Medical Center (URMC) in the laboratory of Prof. Frances Lund, Ph.D. My research focuses on the role of the Ca2+ permeant non-selective cation channel TRPM2 in lung inflammation and Chronic Obstructive Pulmonary Disease (COPD). Using a Trpm2-deficient mouse model, my work aims to determine the involvement of TRPM2 in key inflammatory and oxidative stress signaling processes and to determine whether its absence causes major defects in the infiltration of key inflammatory cells into the lung. The requirement for TRPM2 will be investigated in acute and chronic in vivo models of lung inflammation, which include exposure to lipopolysaccharide (LPS), cigarette smoke and influenza virus. 

1. Botta, D. and Jacobson, M.K. Identification Of a Regulatory Segment Of Poly(ADP-ribose) Glycohydrolase (2010). Biochemistry 49(35):7674-7682.
2. Botta, D., Steffen, J.D., Jacobson, M.K. (2010) Evaluation Of a High-Throughput Colorimetric Assay For Poly(ADP-ribose) Glycohydrolase. In Preparation.
3. Steffen, J.D., Botta, D., Jacobson, M.K. (2010) Evaluation Of Commercially Available High-Throughput Assays For Poly(ADP-ribose) Polymerase. In Preparation.
4. Woodgate, S.R., George, J., Steffen, J.D., Botta, D., Jacobson, M.K. (2010). A Homogeneous Fluorescent Assay For High-Throughput Screening Of Poly(ADP-ribose) Polymerase (PARP) and Poly(ADP-ribose) Glycohydrolase (PARG) Inhibitors. In Preparation.
Originally posted: August 21, 2014
Last updated: October 8, 2015
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