David Klein, PhD

Pharmacology and Toxicology
Pharmacology and Toxicology
Dissertation Title: 
"Nucleoside Transport at the Blood-Testis Barrier"

Year Graduated: 2015
Career Type: Academia
Postdoctoral fellow for Dr. Kim Boekelheide at Brown University

Academic & Professional Updates
My post-doc position is at Brown University in Providence, RI working with Dr. Kim Boekelheide. Dr. Boekelheide is a leading expert in male reproductive toxicology. My project there will be looking for markers of reproductive toxicology. Currently, there are no known markers of testicular damage from a potential toxicant which means if a novel compound is an irreversible toxicant, no screening tools will detect it until patients are already sterile. This project will set the standard for determining markers of potential toxicants thereby improving male reproductive health worldwide.

B.S. Microbiology (2010) Brigham Young University, Provo, Utah

Honors & Achievements
1. 52nd Annual Society of Toxicology Meeting, 3rd Place Carl C. Smith Travel Award, 2013.
2. NIEHS Training Grant - Environmental Toxicology of Human Diseases, 2013, 2014 (33, 34).
3. 1st Place Poster Mountain West Society of Toxicology Poster Award, 2014-15.
4. Graduate Track Awards: Outstanding Research, 2015-16.

1. David M. Klein, Stephen H. Wright, Nathan J. Cherrington. Xenobiotic Transporter Expression Along the Male Genital Tract.
2. David M Klein, Kristen K. Evans, Rhiannon N. Hardwick, William H. Dantzler, Stephen H. Wright, Nathan J. Cherrington. Basolateral Uptake of Nucleosides by Sertoli Cells is Mediated Primarily by Equilibrative Nucleoside Transporter 1 (ENT1).
3. David M. Klein, Stephen H. Wright, Nathan J. Cherrington. Localization of Multidrug Resistance-Associated Proteins Along Blood-Testis Barrier in Rat, Macaque, and Human Testis.
4. Organic and Inorganic transporters of the testis: A review. David M. Klein and Nathan J Cherrington.
5. David Klein, Stephen Wright and Nathan Cherrington. Apical efflux of NRTI in Sertoli cells is mediated by ENT2 in humans and MRP4 in rats. (in press)
6. David Klein, Hui Li, Anika Dzrielegna, and Nathan Cherrington. Localization of nucleoside transporters in the epididymis. (in press)
Originally posted: August 29, 2014
Last updated: October 8, 2015
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