MS & PHD STUDENTS

Cyf Ramos Colón, PhD

Degree: 
PhD
Program: 
Pharmaceutical Sciences
Track: 
Drug Discovery and Development
Dissertation Title: 
Design, Synthesis, and Bioligical Evaluation of Novel Peptide Ligans as Kappa Opioid Receptor Antagonists

Alumna
Year Graduated: 2016
Career Type: Industry
Senior Scientist and Applications Manager at Gyro's Protein Technologies

Academic & Professional Updates
Advisor: Dr. Victor J. Hruby

Education
B.S. Chemistry (2011) University of Arizona, Tucson, Arizona

Honors & Achievements
1. UA NIH Initiative for Maximizing Student Diversity (IMSD) Graduate Study Award, 2011-12.
2. NIDA Diversity Supplement Grant, 2013-14.
3. Graduate Track Awards: Academic Excellence, 2015-16.
4. Marshall Dissertation Fellowship 2016
5. Certificate in College Teaching

Publications

1. Y. S. Lee, D. Rankin, S. M. Hall, C. Ramos-Colon, J. J. Ortiz, R. Kupp, F. Porreca, J. Lai, and V. J. Hruby, “Structure–activity relationships of non-opioid [des-Arg7]-dynorphin A analogues for bradykinin receptors,” Bioorg. Med. Chem. Lett., 4976-4979, 2014.

2. Y. S. Lee, D. Muthu, S. M. Hall, C. Ramos-Colon, D. Rankin, J. Hu, A. J. Sandweiss, M. De Felice, J. Y. Xie, T. W. Vanderah, F. Porreca, J. Lai, and V. J. Hruby, “Discovery of amphipathic dynorphin A analogues to inhibit the neuroexcitatory effects of dynorphin A through bradykinin receptors in the spinal cord,” J. Am. Chem. Soc., 136, 18, 6608–6616, 2014.

3. Y. S. Lee, S. M. Hall, C. Ramos-Colon, M. Remesic, D. Rankin, T. W. Vanderah, F. Porreca, J. Lai, and V. J. Hruby, “Blockade of non-opioid excitatory effects of spinal Dynorphin A at bradykinin receptors,” Recept. Clin. Investig., 2, 2, 2015.

4. Y. S. Lee, S. M. Hall, C. Ramos-Colon, M. Remesic, L. LeBaron, A. Nguyen, D. Rankin, F. Porreca, J. Lai, and V. J. Hruby, “Modification of amphipathic non-opioid dynorphin A analogues for rat brain bradykinin receptors.,” Bioorg. Med. Chem. Lett., 25, 1, 30–33, 2015.

5. Y. S. Lee, R. Kupp, M. V. Remesic, C. Ramos-Colon, S. M. Hall, C. Chan, D. Rankin, J. Lai, F. Porreca, and V. J. Hruby, “Various modifications of the amphipathic dynorphin A pharmacophore for rat brain bradykinin receptors,” Chem. Biol. Drug Des., 88, 4, 615–619, 2016.

6. Y.S. Lee, S. M. Hall, C. Ramos-Colon, D. Muthu, D. Rankin, F. Porreca, J. Lai, V.J. Hruby. “[Des-arg7]-Dynorphin A Analogs for Bradykinin-2 Receptor,” Proceedings of the 23d American Peptide Symposium, 134-135, 2013.               

7. S.M. Hall, Y.S. Lee, C.N. Ramos-Colon, D.R. Rankin, F. Porreca, J. Lai, V.J. Hruby, “Structure Activity Relationship of Dynorphin A (2-13) Analogs at the Bradykinin-2 Receptor,” Proceedings of the 23d American Peptide Symposium, 128-129, 2013.           

8. C.N. Ramos Colon, Y.S. Lee, S.M. Hall, D.R. Rankin, J. Lai, F. Porreca, V.J. Hruby. “Development of Potent Dynorphin A Analogs as Kappa Opioid Receptor Antagonists” Proceedings of the 23d American Peptide Symposium, 142-143, 2013.               

9. Y.S. Lee, S.M. Hall, C. Ramos-Colon, M. Remesic, A. Kuzmin, D. Rankin, T.W. Vanderah, F. Porreca, J. Lai, V.J. Hruby. “Amphipathic Non-opioid Dynorphin A Analogs to Inhibit Neuroexcitatory Effects at Central Bradykinin Receptors,” Proceedings of the 24th American Peptide Symposium, 80-81, 2015.           

10. S.M. Hall, Y.S. Lee, C.N. Ramos Colon, F. Porreca, J. Lai, V.J. Hruby. “Structure Activity Relationship of Stable Dynorphin A-(2-13) Analogues Interacting at the Bradykinin-2 Receptor,” Proceedings of the 24th American Peptide Symposium, 71-72, 2015.       

11. C.N. Ramos Colon, Y.S. Lee, S.M. Hall, J. Lai, F. Porreca, V.J. Hruby. “Structure-Activity Relationship Studies of Dynorphin A Analogs at the Kappa Opioid Receptor,” Proceedings of the 24th American Peptide Symposium, 96-97, 2015.

12. Y.S. Lee, M. Remesic, C. Ramos-Colon, S.M. Hall, A. Kuzmin, D. Rankin, F. Porreca, J. Lai, V.J. Hruby. “Cyclic Non-opioid Dynorphin A Analogues for the Bradykinin Receptors” Bioorg. Med. Chem. Lett., 26 5513-5516, 2016.

13. S.M. Hall, L. LeBaron, C.N. Ramos-Colon, C. Qu, J.Y. Xie, F. Porreca, J. Lai, Y.S. Lee, and V.J. Hruby. “Discovery of Stable Non-opioid Dynorphin A Analogues Interacting at the Bradykinin Receptors for the Treatment of Neuropathic Pain,” ACS Chem. Neurosci., Just Accepted Manuscript. 2016.

14. C. Ramos-Colon, Y.S. Lee, M. Remesic, S. Hall, J. LaVigne, P. Davis, A. Sandweiss, M. McIntosh, J. Hanson, T. Largent-Milnes, T. Vanderah, J. Streicher, F. Porreca, V. Hruby. “Structure Activity Relationships of [des-Arg7]-Dynorphin A Analogues at the k Opioid Receptor,” Just Accepted. J. Med. Chem. 2016.

Originally posted: August 29, 2014
Last updated: February 2, 2017
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