Clement Lin, PhD

Advisor: Danzhou Yang
Status: 
Alumni
Degree: 
PhD
Program: 
Pharmaceutical Sciences
Track: 
Drug Discovery and Development
Dissertation Title: 
DNA and its Secondary Structures as Targets for Small Molecule Anticancer Drugs - An NMR Structural Study
Year Enrolled: 
2010
Phone: 
520-626-7265
Education: 
B.S., Chemistry (2010) Carnegie Mellon University, Pittsburgh, Pennsylvania
Honors and Achievements: 
1. Graduate Track Awards: Outstanding Research, 2014-15.
2. Graduate Track Travel Award, 2014-15.
3. GPSC Travel Award, 2014-15.
Publications: 

1. Solution Structure of a 2:1 Complex of Anticancer Drug XR5944 with TFF1 Estrogen Response Element: Insights Into DNA Recognition by a Bis-Intercalator. Lin C, Mathad RI, Zhang Z, Sidell N, Yang D. Nucleic Acids Res. 2014;42(9):6012-24. doi: 10.1093/nar/gku219. Epub 2014 Apr 7.
2. The Major G-Quadruplex Formed in the Human BCL-2 Proximal Promoter Adopts a Parallel Structure With a 13-nt Loop in K+ Solution. Agrawal P, Lin C, Mathad RI, Carver M, Yang D. J Am Chem Soc. 2014 Feb 5;136(5):1750-3. 
3. Zhang L, Liu H, Shao Y, Lin C, Jia H, Chen G, Yang D, Wang Y. Selective Lighting Up of Epiberberine Alkaloid Fluorescence by Fluorophore-Switching Aptamer and Stoichiometric Targeting of Human Telomeric DNA G-Quadruplex Multimer. Analytical Chemistry 2015, 87(1):730-7.
4. Lin C, Yang D. DNA Recognition By a Novel Bis-Intercalator. The potent Anticancer Drug XR5944. Current Topics in Medicinal Chem 2015, in press.

Alumna or Alumnus: 
Alumnus
Alumni Title/Position/Employer: 
Postdoctoral Associate, Purdue University, West Lafayette, Indiana
Career Type: 
Academia