MS & PHD STUDENTS

Christopher Orton, PhD

Degree: 
PhD
Program: 
Pharmacology and Toxicology
Track: 
Pharmacology and Toxicology
Dissertation Title: 
“Analysis of Protein Adduction Kinetics and the Effects of Protein Adduction on C-Jun N-Terminal Kinase Signaling”

Alumnus
Year Graduated: 2006
Career Type: Academia
Postdoctoral Research Associate, Department of Pharmacology & Toxicology, University of Utah

Academic & Professional Updates
Advisor: Dr. Bernard Futscher
My research focused on studying the effects of protein adduction. I first developed a method to compare the reactivity of multiple adductions sites on the same protein by determining a reactivity constant (k) for each site using quantitative mass spectrometry. The other part of my research entailed looking at the effects of protein adduction on c-Jun N-terminal Kinase (JNK) signaling in HEK293 cells following treatment with two model electrophiles. This work showed differences between two different compounds in their abilities to adduct cellular proteins (including selectivity of JNK signaling related targets) and their abilities to activate JNK.
I am currently beginning a postdoctorate position at the University of Utah working with Gary Yost and Robert Ward studying metabolism of glucocorticoids by the cytochrome P450 3A family of enzymes in lung and respiratory tissues for development of new treatments for asthma geared toward pediatric patients.
Originally posted: August 21, 2014
Last updated: October 8, 2015
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