Christopher Cabello, PhD

Pharmaceutical Sciences
Drug Discovery and Development
Dissertation Title: 
“Attenuated Electrophiles as Redox-Directed Cancer Therapeutics Targeting Skin Cancer.”

Year Graduated: 2013
Career Type: Academia
Chemistry Instructional Faculty, Pima Community College

Academic & Professional Updates
Christopher is currently a Chemistry faculty member at Pima Community College where he teaches General and Organic Chemistry courses for majors and for students seeking acceptance into professional programs in pharmacy and medicine.

Honors & Achievements
1. Graduate Track Awards: Outstanding Research, 2011-12.

1. Park, S.L.; Justiniano, R.; Williams, J.D.; Cabello, C.M.; Qiao, S.; and Wondrak, G.T. The tryptophan-derived endogenous arylhydrocarbon receptor ligand 6-formylindolo[3,2-B]carbazole is a nanomolar UVA-photosensitizer in epidermal keratinocytes. J. Invest. Dermatol. 2014, In press.
2. Davis, A.L.; Qiao, S.; Lesson, J.L.; Rojo de la Vega, M.; Park, S.L.; Seanez, C.M.; Gokhale, V.; Cabello, C.M.; and Wondrak, G.T.  The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells. J. Biol. Chem. 2015, 290(3):1623-38.
3. Davis, A.L.; Cabello, C.M.; Qiao, S.; Azimian, S.; and Wondrak, G.T. Phenotypic identification of the redox dye methylene blue as an antagonist of heat shock response gene expression in metastatic melanoma cells. Int. J. Mol. Sci. 2013, 14(2):4185-202.
4. Qiao, S.; Cabello, C.M.; Lamore, S.D.; Lesson, J.L.; and Wondrak, G.T. D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis. 2012, 17(10):1079-94.
5. Qiao, S.; Lamore, S.D.; Cabello, C.M.; Lesson, J.L.; Munoz-Rodriguez J.L.; and Wondrak, G.T. Thiostrepton is an inducer of oxidative and proteotoxic stress that impairs viability of human melanoma cells but not primary melanocytes. Biochem. Pharm. 2012, 83(9):1229-40.
6. Cabello, C.M.; Lamore, S.D.; Bair, W.B. III; Qiao, S.; Azimian, S.M.; Lesson, J.L.; and Wondrak, G.T. The Redox Antimalarial dihydroartemesinin targets human metastatic melanoma cells but not primary melanocytes with induction of NOXA-dependent apoptosis. Invest New Drugs. 2012, 30(4):1289-1301.
7. Cabello, C.M.; Lamore, S.D.; Bair, W.B. III; Davis, A.L.; Azimian, S.M.; and Wondrak, G.T.  DCPIP (2,6-dichlorophenolindophenol) as a Genotype-Directed Redox Chemotherapeutic Targeting NQO1*2 Breast Carcinoma. Free Radical Res. 2011, 45(3), 276.
8. Lamore, S.D.; Azimian, S.; Horn, D.; Anglin, B.L.; Uchida, K.; Cabello, C.M.; and Wondrak, G.T. The Malondialdehyde-derived Fluorophore DHP-Lysine is a Potent Sensitizer of UVA-induced Photooxidative Stress in Human Skin Cells. J. Photochem Photobiol B. 2010, 101(3), 251.
9. Lamore, S.D.; Cabello, C.M.; and Wondrak, G.T. HMGB1-Directed Drug Discovery Targeting Cutaneous Inflammatory Dysregulation. Current Drug Metab. 2010, 11(13), 250.
10. Bair, W.B.; Cabello, C.M.; Uchida, K.; Bause, A.S.; and Wondrak, G.T. GLO-1 Overexpression in Human Malignant Melanoma. Melanoma Res. 2010, 20, 85.
11. Lamore, S.D.; Cabello, C.M.; and Wondrak, G.T. The Topical Antimicrobial Zinc Pyrithione is a Heat Shock Response Inducer That Causes DNA Damage and PARP-Dependent Energy Crisis in Human Skin Cells. Cell Stress Chaperones.  2010, 15(3), 309.
12. Cabello, C.M.; Bair, W.B.; Bause, A.S.; and Wondrak, G.T. Antimelanoma Activity of the Redox Dye DCPIP (2,6-Dichlorophenolindophenol) is Antagonized by NQO1. Biochem. Pharm. 2009, 78, 344.
13. Cabello, C.M.; Bair, W.B. III, Ley, S,; Lamore, S.D.; Azimian, S.; Wondrak G.T. The Experimental Chemotherapeutic N6-furfuryladenosine (kinetin-riboside) Induces Rapid ATP Depletion, Genotoxic Stress, and CDKN1A(p21) Upregulation in Human Cancer Cell Lines. Biochem. Pharm. 2009, 77(7), 1125.
14. Cabello, C.M.; Bair, W.B. III; Lamore, S.D.; Ley, S.; Bause, A.S.; Azimian, S.; and Wondrak, G.T. The cinnamon-derived Michael aceptor cinnamic aldehyde impairs Melanoma Cell Proliferation, Invasiveness, and Tumor Growth. Free Rad. Biol. Med. 2009, 46(2), 220.
15. Wondrak, G.T.; Cabello, C.M.; Villeneuve, N.F.; Zhang, S.; Ley, S.; Li, Y.; Zheng, S.; and Zhang, D.D. Cinnamoyl-based Nrf2-Activators Targeting Human Skin Cell Photo-oxidative Stress. Free Rad. Biol Med. 2008, 45(4), 385.
16. Cabello, C.M.; Bair, W.B. III; and G.T Wondrak. Experimental therapeutics targeting the redox Achilles heel of cancer. Curr. Opin. Invest. Drugs. 2007, 8(12), 1022.
17. Iranzo, O.,; C. Cabello, and V.L. Pecoraro. Heterochromia in Designed Metallopeptides: Geometry-selective Binding of Cd(II) in a De Novo Designed Peptide. Angew. Chem. Int. Ed. 2007, 46(35), 6688.
18. Lee, K. H., C. Cabello,  E. N. Marsh, L. Hemmingsen, V. L. Pecoraro. Using Nonnatural Amino Acids to Control Metal Coordination in Three-Stranded Coiled Coils. Angew. Chem. Int. Ed. 2006, 45, 2864.
Originally posted: August 22, 2014
Last updated: October 8, 2015
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