Christine Kaiser, PhD

Pharmaceutical Sciences
Drug Discovery and Development
Dissertation Title: 
"Characterization and Targeting of The Multiple DNA Secondary Structures in The KRAS Proximal Promoter to Modulate Gene Expression"

Year Graduated: 2015
Career Type: Academia
Post-doctoral fellow at AstraZeneca in Boston, MA

Academic & Professional Updates
In the lab of Laurence Hurley, I focused on understanding how the unique arrangement of DNA secondary structures—the G-quadruplex and the i-Motif—function to modulate gene expression in the promoter of the KRAS proto-oncogene. Additionally, I utilized structure based design and compound screening to identify compounds that interact with these structures to downregulate gene expression. To date, we have identified two distinct compounds capable of modulating KRAS gene expression; the most active compound has shown activity in pancreatic cancer, multiple myeloma, and colon cancer.

BS, Biochemistry (2010) Arizona State University BS, Mathematics (2010) Arizona State University

Honors & Achievements
1. NIH Training Grant Research Fellowship-Biological Chemistry Program, 2011-12.
2. Mary E. Caldwell Memorial Scholarship, 2012-13.
3. NIH Training Grant Research Fellowship-Biological Chemistry Program, 2012-13.
4. Graduate Track Awards: Outstanding Research, 2013-14.
5. American Chemical Society Division of Medicinal Chemistry Predoctoral Fellowship, 2013-14.
6. Hugh E. Laird II Memorial Fellowship, 2013-14.
7. PEO Scholar Award, 2014-15.

1. Kaiser, C. E.; Gokhale, V.; Yang, D.; Hurley, L. H. (2013) “Gaining insights into the small molecule targeting of the G-quadruplex in the c-MYC promoter using NMR and an allele-specific transcriptional assay.”  In Topics in Current Chemistry—Quadruplex Nucleic Acids, Jonathan B. Chaires and David Graves, editors.  Springer-Verlag, Berlin, Heidelberg; Vol. 330, pp. 1–22.
2. Wang Y and Kaiser CE*, Frett B, Li H. Targeting mutant KRAS for anticancer therapeutics: a review of novel small molecule modulators. J Med Chem. (2013) 56:5219-5230.
3. Gunawan S, Ayaz M, De Moliner F, Frett B, Kaiser C, Patrick N, Xu Z, Hulme C. Synthesis of tetrazolo-fused benzodiazepines and benzodiazepinones by a two-step protocol using an Ugi-Azide reaction for initial diversity generation. Tetrahedron (2012) 68: 5606-5611.
4. Nichol GS, Xu Z, Kaiser CE, Hulme C. 4-(Piperidin-1-yl)-4H-benzo[b]tetrazolo[1,5-d][1,4]diazepin-5(6H)-one. Acta Cryst. (2011) E67: o23-o24.
5. Petit, J.; Meurice, N.; Kaiser CE; Maggiora, G. Softening the Rule of Five—where to draw the line? Bioorg. Med. Chem. 2012, 20, 5343–5351.
Originally posted: August 29, 2014
Last updated: December 21, 2016
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