Bryan Harder

Pharmacology and Toxicology
Pharmacology and Toxicology
Dissertation Title: 
Molecular and chemical modulation of NRF2 for disease intervention

Year Graduated: 2017
Career Type: Health Care
Post-doctoral Research Fellow at the Mayo Clinic in Arizona

Academic & Professional Updates

Cancer research.

B.S. Biological Sciences-Animal Physiology & Behavior (2012) Minor in chemistry Arizona State University, Tempe Arizona

Honors & Achievements
1. NIEHS Training Grant - Environmental Toxicology of Human Diseases, 2014 (34).
2. Hugh E. Laird II PhD Memorial Fellowship Award, 2014-15.
3. SOT Graduate Student Travel Award, 2014-15.
4. Carl C. Smith Graduate Student Award (3rd Place).


Tillotson J, Zerio CJ, Harder B, Ambrose AJ, Jung KS, Kang M, Zhang DD, Chapman E (2017) Arsenic Compromises Both p97 and Proteasome Functions. Chem Res Toxicol.

Harder B, Tian W, La Clair JJ, Tan AC, Ooi A, Chapman E, and Zhang DD (2016) Brusatol overcomes chemoresistance through inhibition of protein translation. Molecular carcinogenesis.

Corenblum MJ, Ray S, Remley QW, Long M, Harder B, Zhang DD, Barnes CA, Madhavan L. (2016) Reduced Nrf2 expression mediates the decline in neural stem cell function during a critical middle-age period. Aging Cell.

Harder B, Jiang T, Wu T, Tao S, Rojo de la Vega M, Tian W, Chapman E, and Zhang DD. (2015) Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention. Biochem Soc Trans.

Jiang T, Harder B, Rojo de la Vega M, Wong PK, Chapman E, and Zhang DD. (2015) p62 links autophagy and Nrf2 signaling. Free Radic Biol Med.

Canet MJ, Merrell MD, Harder BG, Maher JM, Wu T, Lickteig AJ, Jackson JP, Zhang DD, Yamamoto M, Cherrington NJ. (2015) Identification of a Functional Antioxidant Response Element within the Eighth Intron of the Human ABCC3 Gene. Drug Metab Dispos.

Wu T, Harder BG, Wong PK, Lang JE, Zhang DD. (2014) Oxidative stress, mammospheres and Nrf2-new implication for breast cancer therapy? Molecular carcinogenesis.

Tao Shen, Xue-Mei Chen, Bryan Harder, Min Long, Xiao-Ning Wang, Hong Xiang Lou, Georg T. Wondark, Dong-Mei Ren, Donna D. Zhang. (2013) Plant Extracts of the Family Lauraceae: A Potential Resource for Chemopreventive Agents that Activates the Nrf2/ARE Pathway. Planta Medica.

Originally posted: August 29, 2014
Last updated: September 13, 2017
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